Historique
Article de Périodique
Acute neonatal effects of cocaine exposure during pregnancy (2005)
(Effets aigus néonataux de l'exposition à la cocaïne durant la grossesse)
Auteur(s) :
BAUER, C. R. ;
LANGER, J. C. ;
SHANKARAN S. ;
BADA, H. S. ;
LESTER, B. ;
WRIGHT, L. L. ;
KRAUSE-STEINRAUF, H. ;
SMERIGLIO V. L. ;
FINNEGAN, L. P. ;
MAZA P. L. ;
VERTER J.
Année
2005
Page(s) :
824-834
Langue(s) :
Anglais
Refs biblio. :
47
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
GROSSESSE
;
NOUVEAU-NE
;
ETUDE PROSPECTIVE
;
SYMPTOME
;
DEPISTAGE
Thésaurus géographique
ETATS-UNIS
Résumé :
OBJECTIVE: To identify associations between cocaine exposure during pregnancy and medical conditions in newborn infants from birth through hospital discharge. DESIGN: Multisite, prospective, randomized study. SETTING: Brown University, University of Miami, University of Tennessee (Memphis), and Wayne State University.Subjects A total of 717 cocaine-exposed infants and 7442 nonexposed infants. MAIN OUTCOME MEASURES: Results of physical examination and conditions observed during hospitalization. RESULTS: Cocaine-exposed infants were about 1.2 weeks younger, weighed 536 g less, measured 2.6 cm shorter, and had head circumference 1.5 cm smaller than nonexposed infants (all P<.001). Results did not confirm previously reported abnormalities. Central and autonomic nervous system symptoms were more frequent in the exposed group: jittery/tremors (adjusted odds ratio, 2.17; 99% confidence interval, 1.44-3.29), high-pitched cry (2.44; 1.06-5.66), irritability (1.81; 1.18-2.80), excessive suck (3.58; 1.63-7.88), hyperalertness (7.78; 1.72-35.06), and autonomic instability (2.64; 1.17-5.95). No differences were detected in organ systems by ultrasound examination. Exposed infants had more infections (3.09; 1.76-5.45), including hepatitis (13.46; 7.46-24.29), syphilis (8.84; 3.74-20.88), and human immunodeficiency virus exposure (12.37; 2.20-69.51); were less often breastfed (0.26; 0.15-0.44); had more child protective services referrals (48.92; 28.77-83.20); and were more often not living with their biological mother (18.70; 10.53-33.20). CONCLUSIONS: Central and autonomic nervous system symptoms were more frequent in the exposed cohort and persisted in an adjusted analysis. They were usually transient and may be a true cocaine effect. Abnormal anatomic outcomes previously reported were not confirmed. Increased infections, particularly sexually transmitted diseases, pose a serious public health challenge. Exposure increased involvement of child protective services and out-of-home placement.
Affiliation :
Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
Cote :
A02823