Historique
Périodique
Alcohol and cancer
Auteur(s) :
BOFFETTA, P. ;
HASHIBE, M.
Année
2006
Page(s) :
149-156
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
75
Domaine :
Alcool / Alcohol
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
ALCOOL
;
MECANISME D'ACTION
;
CANCER
;
PATHOLOGIE ORGANIQUE
;
FACTEUR DE RISQUE
;
METABOLISME
Note générale :
Lancet Oncology, 2006, 7, (2), 149-156
Résumé :
A causal association has been established between alcohol consumption and cancers of the oral cavity, pharynx, larynx, oesophagus, liver, colon, rectum, and, in women, breast; an association is suspected for cancers of the pancreas and lung. Evidence suggests that the effect of alcohol is modulated by polymorphisms in genes encoding enzymes for ethanol metabolism (eg, alcohol dehydrogenases, aldehyde dehydrogenases, and cytochrome P450 2E1), folate metabolism, and DNA repair. The mechanisms by which alcohol consumption exerts its carcinogenic effect have not been defined fully, although plausible events include: a genotoxic effect of acetaldehyde, the main metabolite of ethanol; increased oestrogen concentration, which is important for breast carcinogenesis; a role as solvent for tobacco carcinogens; production of reactive oxygen species and nitrogen species; and changes in folate metabolism. Alcohol consumption is increasing in many countries and is an important cause of cancer worldwide.
Affiliation :
Gene-Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69008 Lyon.
France. France.
France. France.
Cote :
A02873