Historique
Article de Périodique
A preliminary DTI study showing no brain structural change associated with adolescent cannabis use (2006)
(Une étude préliminaire d'ITD (imagerie du tenseur de diffusion) ne montrant aucun changement dans la structure cérébrale, associé à l'usage de cannabis chez l'adolescent.)
Auteur(s) :
DELISI L. E. ;
BERTISCH, H. C. ;
SZULC K.U. ;
MAJCHER M. ;
BROWN, K. ;
BAPPAL, A. ;
ARDEKANI, B. A.
Année
2006
Page(s) :
1-6
Langue(s) :
Français
Refs biblio. :
25
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CANNABIS
;
ETUDE CAS-TEMOINS
;
ADOLESCENT
;
CERVEAU
;
IMAGERIE MEDICALE
;
ANCIEN FUMEUR
Note générale :
Harm Reduction Journal, 2006, 3, (17), 1-6
Résumé :
ENGLISH :
Analyses were performed on brain MRI scans from individuals who were frequent cannabis users (N = 10; 9 males, 1 female, mean age 21.1 + 2.9, range: 18-27) in adolescence and similar age and sex matched young adults who never used cannabis (N = 10; 9 males, 1 female, mean age of 23.0 + 4.4, range: 17-30). Cerebral atrophy and white matter integrity were determined using diffusion tensor imaging (DTI) to quantify the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA). Whole brain volumes, lateral ventricular volumes, and gray matter volumes of the amygdala-hippocampal complex, superior temporal gyrus, and entire temporal lobes (excluding the amygdala-hippocampal complex) were also measured. While differences existed between groups, no pattern consistent with evidence of cerebral atrophy or loss of white matter integrity was detected. It is concluded that frequent cannabis use is unlikely to be neurotoxic to the normal developing adolescent brain.
Affiliation :
The Center for Advanced Brain Imaging, The Nathan S, Kline Institute for Psychiatric Research, Orangeburg, New York. Email : DeLisi76@AOL.com
Etats-Unis. United States.
Etats-Unis. United States.