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Antiemetic efficacy of smoked marijuana. Subjective and behavioral effects on nausea induced by syrup of ipecac
(Efficacité antiémétique du cannabis fumé. Effets subjectifs et comportementaux sur les nausées induites par du syrop d'ipécac)
Auteur(s) :
SÖDERPALM A. H. V. ;
SCHUSTER, A. ;
DE WIT, H.
Année
2001
Page(s) :
p.343-350
Langue(s) :
Anglais
ISBN :
0091-3057
Refs biblio. :
25
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CANNABIS
;
ONDANSETRON
;
TETRAHYDROCANNABINOL
;
USAGE THERAPEUTIQUE
;
EFFICACITE
;
NAUSEE
Note générale :
Pharmacology, Biochemistry and Behavior, 2001, 69, 343-350
Résumé :
Although the public debate about the legalization of marijuana has continued for as long as 25 years, few controlled studies have been conducted to assess its potential medical benefits. The present study examined the antiemetic effect of smoked marijuana cigarettes (8.4 and 16.9 mg D9-tetrahydrocannabinol [THC]) compared to a highly potent antiemetic drug, ondansetron (8 mg) in 13 healthy volunteers. Nausea and emesis were induced by syrup of ipecac. Marijuana significantly reduced ratings of queasiness and slightly reduced the incidence of vomiting compared to placebo. Ondansetron completely eliminated the emetic effects of ipecac. These findings support and extend previous results, indicating that smoked marijuana reduces feelings of nausea and also reduces emesis in this model. However, its effects are very modest relative to ondansetron, and the psychoactive effects of marijuana are likely to limit its clinical usefulness in the general population. (Author' s abstract)
Affiliation :
Department of Psychiatry, The University of Chicago, MC3077, 5841 S. Maryland Avenue, Chicago, IL 60637.
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A02933