Historique
Périodique
Chronic effects of marihuana smoking on luteinizing hormone, follicle-stimulating hormone and prolactin levels in human males
(Effets chroniques de la marihuana fumée sur les hormones lutéinisante, folliculostimulante et la prolactine chez l'homme)
Auteur(s) :
VESCOVI, P. P. ;
PEDRAZZONI M. ;
MICHELINI M. ;
MANINETTI L. ;
BERNARDELLI, F. ;
PASSERI M.
Année
1992
Page(s) :
59-63
Langue(s) :
Français
ISBN :
0376-8716
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Drug and Alcohol Dependence, 1992, 30, 59-63
Résumé :
FRANÇAIS :
Les taux des trois hormones LH, FSH et PRL sont comparés chez dix hommes témoins et dix hommes fumeurs de marihuana, avant et après injection intraveineuse de thyrotropine releasing hormone (TRH) et d'hormone gonadotrope (Gn RH). Seul le niveau de base (ou après stimulation) de la LH est réduit chez les fumeurs de marihuana. On déduit que l'usage chronique de marijuana pourrait modifier sélectivement les mécanismes de contrôle hypothalamique de régulation hormonale.
ENGLISH :
The purpose of this investigation was to assess the chronic effects of marihuana smoking on the basal and stimulated secretion of the pituitary hormones luteinizing hormone (LH), follicle-stimulating (FSH) and prolactin (PRL). Ten male chronic marijuana users and 10 age and sex -matched healthy volunteers were studied by measuring hormone levels before and after i.v. administration of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (GnRH). The basal and stimulated levels of LH were reduced in marihuana users, whereas FSH and PRL levels and responses were not different from the control subjects. The chronic use of marihuana may selectively impair the hypothalamic control mechanisms regulating LH secretion. (Author's abstract)
Les taux des trois hormones LH, FSH et PRL sont comparés chez dix hommes témoins et dix hommes fumeurs de marihuana, avant et après injection intraveineuse de thyrotropine releasing hormone (TRH) et d'hormone gonadotrope (Gn RH). Seul le niveau de base (ou après stimulation) de la LH est réduit chez les fumeurs de marihuana. On déduit que l'usage chronique de marijuana pourrait modifier sélectivement les mécanismes de contrôle hypothalamique de régulation hormonale.
ENGLISH :
The purpose of this investigation was to assess the chronic effects of marihuana smoking on the basal and stimulated secretion of the pituitary hormones luteinizing hormone (LH), follicle-stimulating (FSH) and prolactin (PRL). Ten male chronic marijuana users and 10 age and sex -matched healthy volunteers were studied by measuring hormone levels before and after i.v. administration of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (GnRH). The basal and stimulated levels of LH were reduced in marihuana users, whereas FSH and PRL levels and responses were not different from the control subjects. The chronic use of marihuana may selectively impair the hypothalamic control mechanisms regulating LH secretion. (Author's abstract)
Affiliation :
Inst. Clin. Med. Gen. Terap. Med., Univ. Parma, Via Gramsci 14, 43100 Parma
Italie. Italy.
Italie. Italy.
Cote :
A02948