Historique
Article de Périodique
Comparing treatments of alcoholism on craving and biochemical measures of alcohol consumptions (2006)
Auteur(s) :
NAVA F. ;
PREMI S. ;
MANEATO E. ;
LUCCHINI A.
Année
2006
Page(s) :
211-228
Langue(s) :
Anglais
Refs biblio. :
36
Domaine :
Alcool / Alcohol
Thésaurus mots-clés
ALCOOL
;
TRAITEMENT
;
COMPARAISON
;
ENQUETE
;
EFFICACITE
;
EVALUATION
;
GHB
;
COMPULSION
;
BIOCHIMIE
Note générale :
Journal of Psychoactive Drugs, 2006, 38, (3), 211-228
Note de contenu :
tabl.
Résumé :
ENGLISH :
An open randomized study was conducted to compare different treatments of alcoholism on ethanol intake, craving, and on biochemical measures of alcohol consumptions. Eighty-six alcoholics were abstinent for a mean of two weeks prior to random assignment to g-hydroxybutyrate (GHB, 50 mg/kg of body weight t.i.d), naltrexone (NTX, 50 mg/day) or disulfiram (DSF, 200 mg/ day) treatment for 12 months. All treatments were equally effective in reducing alcohol intake and in maintaining abstinence. In all patients, the treatments were able to reduce both craving and the altered biological markers of alcohol abuse. The maximum effects were observed in GHB-treated patients. The results of the present study suggest that GHB might act both as anticraving and cellular protector agent.
Affiliation :
Italie. Italy.
Cote :
Abonnement