Historique
Article de Périodique
Single dose of 24 milligrams of buprenorphine for heroin detoxification : an open-label study of five inpatients (2006)
(Dose simple de 24 milligrammes de buprénorphine pour le sevrage de l'héroïne : étude non masquée de 5 patients hospitalisés)
Auteur(s) :
ANG-LEE, K. ;
ORESKOVITCH M.R. ;
SAXON, A. J. ;
JAFFE C. ;
MEREDITH, C. ;
ELLIS, M. ;
MALTE C.A. ;
KNOX, P. C.
Année
2006
Page(s) :
505-512
Langue(s) :
Anglais
Refs biblio. :
23
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Journal of Psychoactive Drugs, 2006, 38, (4), 505-512
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Previous studies indicate that buprenorphine has efficacy in medically supervised opioid withdrawal, but the optimal dosing for maximum tolerability and ease of administration remains undetermined. Five heroin-dependent individuals entered this open-label study of inpatient detoxification with a single 24mg dose of buprenorphine. The mean Clinical Opiate Withdrawal Scale (COWS) score prior to buprenorphine administration was 17.6 (SD = 3.36). COWS scores declined significantly thereafter. There was one episode of precipitated withdrawal that resolved within four hours. Use of ancillary medications was minimal. This study suggests that a single high dose of buprenorphine can be used safely and effectively for inpatient detoxification.
Affiliation :
Etats-Unis. United States.
Cote :
Abonnement