Historique
Périodique
An open-label pilot study of methylphenidate in the treatment of cocaine dependennt patients with adult attention deficit/hyperactivity disorder
(Etude pilote non-masquée de la méthylphénidate dans le traitement de patients dépendant de la cocaïne et présentant des troubles d'hyperactivité avec déficit de l'attention.)
Auteur(s) :
SOMOZA E. C. ;
WINHUSEN, T. M. ;
BRIDGE, T. P. ;
ROTROSEN, J. P. ;
VANDERBURG D. G. ;
HARRER, J. M. ;
MEZINSKIS J. P. ;
MONTGOMERY, M. A. ;
CIRAULO, D. A. ;
WULSIN L. R. ;
BARRETT, J. A.
Année
2004
Page(s) :
77-92
Langue(s) :
Français
Refs biblio. :
28
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Journal of Addictive Diseases, 2004, 23, (1), 77-92
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
A multi-site, open-label study of methylphenidate for treating patients with comorbid diagnoses of attention deficit/hyperactivity disorder and cocaine dependence was performed. Forty-one participants, who met DSM-IV criteria for adult attention deficit/hyperactivity disorder and cocaine dependence, were enrolled into this ten week outpatient study. The targeted total daily dose of methylphenidate was 60 mg (20 mg TID). Participants received individual substance abuse therapy throughout the trial. Safety measures included adverse events, vital signs, and electrocardiograms. Methylphenidate's efficacy was assessed by both objective and subjective measures. Seventy percent of the participants completed final study measures. Safety measures indicated that methylphenidate was well tolerated by the participants. Subjective efficacy measures suggested that participants evidenced improvement in both cocaine dependence and adult attention deficit/hyperactivity disorder symptoms. Quantitative benzoylecgonine indicated that only those participants categorized as being compliant showed improvement. A double-blind, placebo-controlled study of methylphenidate for this population may be warranted. (Review' s abstract)
Affiliation :
CinARC, 3210 Jefferson Av., Cincinnati, OH 45220 ; somoza@uc.edu
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A03218