Historique
Article de Périodique
MDMA (Ecstasy) (2007)
Auteur(s) :
EL-MALLAKH, R. S. ;
ABRAHAM, H. D.
Année
2007
Page(s) :
45-52
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
163
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TYPE D'USAGE
;
MDMA-ECSTASY
;
MECANISME D'ACTION
;
DROGUES DE SYNTHESE
;
DEPENDANCE
;
TOXICITE
Résumé :
BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a synthetic amphetamine analogue that is recreationally used to obtain a psychological effect of enhanced affiliative emotional response. Its use in Western countries appears to be increasing, particularly among young individuals. METHODS: Pertinent basic and clinical literature is critically reviewed. RESULTS: A significant body of literature suggests that the patterns of MDMA use differ from traditional drugs of abuse, with relatively uncommon dependence and escalation of dosage. Nonetheless, MDMA is also neurotoxic with significant deleterious effects on serotonergic neurons, memory, and mood. Despite this, there is a dearth of treatment strategies for both acute intoxication and consequences of longer term use. CONCLUSIONS: MDMA is an important drug of abuse that has a wide range of adverse consequences. (Author's abstract)
Affiliation :
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, Etats-Unis. United States.
Cote :
A03290