Historique
Article de Périodique
The environment and schizophrenia: the role of cannabis use (2005)
Auteur(s) :
HENQUET, C. ;
MURRAY, R. ;
LINSZEN, D. ;
VAN OS, J.
Année
2005
Page(s) :
608-612
Sous-type de document :
Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
31
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
ENVIRONNEMENT
;
PSYCHOSE
;
GENETIQUE
;
MILIEU SOCIOCULTUREL
;
FACTEUR DE RISQUE
;
SCHIZOPHRENIE
Résumé :
Cannabis use is associated with poor outcome in existing schizophrenia and may precipitate psychosis in individuals with preexisting liability. To investigate the overall effect size and consistency of the association between cannabis and psychosis, a meta-analysis from prospective studies was carried out. The pooled odds ratio was 2.1 (95% CI: 1.7-2.5) and could not be explained by confounding or reverse causality. Evidence suggests that cannabis is a component cause in the development and prognosis of psychosis, in which mechanisms of gene-environment interaction are most likely to explain this association. Potential new methods to directly link genetic liability to the effects of cannabis are discussed. (Author' s abstract)
Affiliation :
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
Cote :
A03384