Historique
Périodique
Vaccine immunogenicity in injecting drug users: a systematic review
(Immunogénicité vaccinale chez les usagers de drogues par injection : une revue systématique de la littérature.)
Auteur(s) :
BARAL, S. ;
SHERMAN, S. G. ;
MILLSON, P. ;
BEYRER, C.
Année
2007
Page(s) :
667-674
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Français
Refs biblio. :
114
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus géographique
INTERNATIONAL
Thésaurus mots-clés
INJECTION
;
SYSTEME IMMUNITAIRE
;
VACCINATION
;
HEPATITE
;
INFECTION
;
VIH
;
VIRUS
;
TETANOS
Note générale :
Lancet Infectious Diseases (The), 2007, 7, (10), 667-674
Résumé :
ENGLISH :
Injection drug use is a prevalent global phenomenon; one not bound by a country's level of development or geographical location. Injection drug users (IDUs) are at high risk for a variety of parenterally acquired and transmitted infections. Licensed vaccines are available for some of these infectious diseases, such as tetanus, influenza, and hepatitis A and B viruses; however, there have been conflicting reports as to their immunogenicity in IDUs. We summarise the lessons learned from studies evaluating the immunogenicity of vaccination strategies in IDUs. A common theme across these diseases is that although there is a tendency towards decreased antibody responses after immunisation, there is no conclusive evidence linking these observations to a decrease in clinical protection from infection. There is a clear need for definitive studies of vaccination strategies in IDUs; however, a synthesis of the available published evidence suggests that immunisation does result in effective clinical protection from disease in this population. The inclusion of IDUs as a high-risk study population in future trials evaluating HIV and hepatitis C virus vaccines will help to assess the immunogenicity of candidate vaccines against parenteral exposure, and also to evaluate the efficacy of candidates as promising antigens become available. (Author' s abstract)
Affiliation :
Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205. Email : sbaral@jhsph.edu
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A03446