Historique
Périodique
Cannabis and alcohol - a close friendship
Auteur(s) :
MECHOULAM, R. ;
PARKER, L.
Année
2003
Page(s) :
266-268
Langue(s) :
Anglais
Refs biblio. :
24
Domaine :
Plusieurs produits / Several products
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ALCOOL
;
CANNABIS
;
CANNABINOIDES
;
MODELE ANIMAL
;
NEUROBIOLOGIE
;
PHYSIOLOGIE
;
RENFORCEMENT
Note générale :
Trends in Pharmacological Sciences, 2003, 24, (6), 266-268
Résumé :
ENGLISH :
Cannabinoids and alcohol activate the same reward pathways, and the cannabinoid CB(1) receptor system plays an important role in regulating the positive reinforcing properties of alcohol. Indeed, both cannabinoids and alcohol cause the release of dopamine in the nucleus accumbens. Recent research suggests that ethanol preference, which is dependent on CB(1) receptors, is higher in young mice than in old mice, and higher in female mice than in male mice. (Author' s abstract)
Affiliation :
Hebrew University Medical Faculty, Pharmacy School Department of Medicinal Chemistry and Natural Products, Jerusalem 91120. Email : Mechou@cc.huji.ac.il
Israël. Israel.
Israël. Israel.
Cote :
A03592