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Interactions of HIV and methamphetamine: cellular and molecular mechanisms of toxicity potentiation
(Interactions entre VIH et méthamphétamine : mécanismes cellulaires et moleculaires de la potentiation de la toxicité.)
Auteur(s) :
CADET, J. L. ;
KRASNOVA I. N.
Année
2007
Page(s) :
181-204
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Français
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Note générale :
Neurotoxicity Research, 2007, 12, (3), 181-204
Résumé :
ENGLISH :
Methamphetamine (METH) is a highly addictive psychostimulant drug, whose abuse has reached epidemic proportions worldwide. METH use is disproportionally represented among populations at high risks for developing HIV infection or who are already infected with the virus. Psychostimulant abuse has been reported to exacerbate the cognitive deficits and neurodegenerative abnormalities observed in HIV-positive patients. Thus, the purpose of the present paper is to review the clinical and basic observations that METH potentiates the adverse effects of HIV infection. An additional purpose is to provide a synthesis of the cellular and molecular mechanisms that might be responsible for the increased toxicity observed in co-morbid patients. The reviewed data indicate that METH and HIV proteins, including gp120, gp41, Tat, Vpr and Nef, converge on various caspase-dependent death pathways to cause neuronal apoptosis. The role of reactive microgliosis in METH- and in HIV-induced toxicity is also discussed. (Author' s abstract)
Affiliation :
Molecular Neuropsychiatry Branch, NIH/NIDA Intramural Research Program, Baltimore, MD 21224. Email : jcadet@intra.nida.nih.gov
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A03611