Historique
Périodique
Determination of a newly encountered designer drug "p-methoxyethylamphetamine" and its metabolites in human urine and blood
Auteur(s) :
ZAITSU, K. ;
KATAGI M. ;
KAMATA T. ;
KAMATA H. ;
SHIMA N. ;
TSUCHIHASHI H. ;
HAYASHI T. ;
KUROKI H. ;
MATOBA R.
Année
2008
Page(s) :
77-84
Langue(s) :
Français
Refs biblio. :
32
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
URINE
;
SANG
;
DROGUES DE SYNTHESE
;
ANALYSE CHIMIQUE
;
DEPISTAGE
;
TOXICOLOGIE
;
MEDECINE LEGALE
;
METHODE
Thésaurus géographique
JAPON
Note générale :
Forensic Science International, 2008, 177, (1), 77-84
Résumé :
ENGLISH :
A newly synthesized designer drug, para-methoxyethylamphetamine (PMEA) was unexpectedly detected in the postmortem specimens of fatality involving drug intoxication in 2005, Japan. For unequivocal identification, the isomeric discrimination of PMEA and its positional-isomers was performed by GC/MS with the trifluoroacetylation. In order to prove the intake of PMEA, the characteristic metabolites of PMEA were also identified by GUMS analysis of the urine specimen with trifluoroacetylation. As a result, para-methoxyamphetamine, para-hydroxyethylamphetamine (POHEA) and para-hydroxyamphetamine were identified as the major metabolites of PMEA. For the quantitative analyses of PMEA and its three metabolites in body fluids, an automated column-switching LC/MS procedure was developed, and applied to the postmortem blood and urine specimens. In this fatal case, blood concentration of PMEA was estimated to be 12.2 ug/mL and this level seemed extremely high in comparison with lethal blood-levels of its analogues, representing acute-intoxication of the victim. Based on the quantitative results, PMEA was found to be extensively metabolized to POHEA via O-demethylation, partly followed by its conjugation. (c) 2007 Elsevier Ireland Ltd. All rights reserved. (Author' s abstract)
Affiliation :
Japon. Japan.
Cote :
A03625