Historique
Article de Périodique
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis (2008)
(Les effets du cannabidiol sur les symptômes de type schizophrénie chez les individus utilisant du cannabis)
Auteur(s) :
MORGAN, C. J. ;
CURRAN, H. V.
Année
2008
Page(s) :
306-307
Langue(s) :
Anglais
Refs biblio. :
11
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
CANNABIDIOL
;
CANNABINOIDES
;
TETRAHYDROCANNABINOL
;
PHANERES
;
PSYCHOSE
Résumé :
Cannabis contains various cannabinoids, two of which have almost opposing actions: Δ9-tetrahydrocannabinol (Δ9-THC) is psychotomimetic, whereas cannabidiol (CBD) has antipsychotic effects. Hair samples were analysed to examine levels of Δ9-THC and CBD in 140 individuals. Three clear groups emerged: 'THC only', 'THC+CBD' and those with no cannabinoid in hair. The THC only group showed higher levels of positive schizophrenia-like symptoms compared with the no cannabinoid and THC+CBD groups, and higher levels of delusions compared with the no cannabinoid group. This provides evidence of the divergent properties of cannabinoids and has important implications for research into the link between cannabis use and psychosis.
Affiliation :
Clinical Psychopharmacology Unit, Sub-Department of Clinical Health Psychology, University College London, London, UK
Cote :
A03711