Historique
Article de Périodique
Meta-regression of hepatitis C virus infection in relation to time since onset of illicit drug injection: the influence of time and place (2008)
Auteur(s) :
HAGAN, H. ;
POUGET, E. R. ;
DES JARLAIS, D. C. ;
LELUTIU-WEINBERGER, C.
Année
2008
Page(s) :
1099-1109
Sous-type de document :
Méta-analyse / Meta-analysis
Langue(s) :
Anglais
Refs biblio. :
94
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
HEPATITE
;
INFECTION
;
INJECTION
;
REDUCTION DES RISQUES ET DES DOMMAGES
;
VIH
;
PREVALENCE
;
MODELE
;
FACTEUR DE RISQUE
Résumé :
The authors examined the relation between time since onset of illicit drug injection (time at risk) and rates of hepatitis C virus (HCV) infection by using meta-regression. In 72 prevalence studies, median time since onset of injection was 7.24 years and median prevalence was 66.02%. The model showed statistically significant linear and quadratic effects of time at risk on HCV prevalence and significantly higher prevalence in developing and transitional countries and in earlier samples (1985-1995). In developed countries post-1995, mean fitted prevalence was 32.02% (95% confidence interval: 25.31, 39.58) at 1 year of injection and 53.01% (95% confidence interval: 40.69, 65.09) at 5 years. In developing/transitional countries post-1995, mean fitted HCV prevalence was 59.13% (95% confidence interval: 30.39, 82.74) at 1 year of injection. In 10 incidence studies, median time at risk was 5.29 years and median cumulative HCV incidence was 20.69%. Mean fitted cumulative incidence was 27.63% (95% confidence interval: 16.92, 41.70) at 1 year of drug injection. The authors concluded that time to HCV infection in developed countries has lengthened. More rapid onset of HCV infection in drug injectors in developing/transitional countries resembles an earlier era of the HCV epidemic in other regions. (Author' s abstract)
Affiliation :
Center for Drug Use and HIV Research, National Development and Research Institutes (NDRI), New York, NY
Cote :
A03808