Historique
Périodique
Substance abuse vaccines
Auteur(s) :
ORSON, F. M. ;
KINSEY, B. M. ;
SINGH, R. A. ;
WU, Y. ;
GARDNER, T. ;
KOSTEN, T. R.
Année
2008
Page(s) :
257-269
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
ISBN :
1749-6632
Refs biblio. :
68
Domaine :
Plusieurs produits / Several products
Thésaurus mots-clés
ANTICORPS
;
IMMUNOLOGIE
;
VACCINATION
;
THEORIE
;
COCAINE
;
NICOTINE
;
MORPHINE
;
METHAMPHETAMINE
;
PHENCYCLIDINE
;
PHARMACOCINETIQUE
Note générale :
Annals of the New York Academy of Sciences, 2008, 1141, 257-269
Résumé :
Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advanced stages of development. Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies in the bloodstream, thereby blocking entry and/or reducing the rate of entry of the drug into the central nervous system. The benefits of such antibodies on drug pharmacodynamics will be influenced by both the quantitative and the qualitative properties of the antibodies. The sum of these effects will determine the success of the clinical applications of antidrug vaccines in addiction medicine. This review will discuss these issues and present the current status of vaccine development for nicotine, cocaine, methamphetamine, phencyclidine, and morphine. (Author's abstract)
Affiliation :
Veterans Affairs Medical Center, Houston, TX, USA
Cote :
A03874