Historique
Article de Périodique
Preference for buprenorphine/naloxone and buprenorphine among patients receiving buprenorphine maintenance therapy in France: a prospective, multicenter study (2010)
Auteur(s) :
DAULOUEDE, J. P. ;
CAER, Y. ;
GALLAND, P. ;
VILLEGER, P. ;
BRUNELLE, E. ;
BACHELLIER, J. ;
PIQUET J. M. ;
HARBONNIER, J. ;
LEGLISE, Y. ;
COURTY, P.
Année
2010
Page(s) :
83-89
Langue(s) :
Français
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
SUBSTITUTION
;
PREFERENCE
;
TRAITEMENT DE MAINTENANCE
;
SATISFACTION
;
BUPRENORPHINE
;
NALOXONE
;
ETUDE PROSPECTIVE
Thésaurus géographique
FRANCE
Note générale :
Journal of Substance Abuse Treatment, 2010, 38, (1), 83-89
Résumé :
ENGLISH :
Maintenance treatment with buprenorphine tablets (Subutex) has been associated with reductions in heroin use; however, concerns for intravenous misuse exist. A buprenorphine/naloxone formulation (Suboxone) was designed to reduce this misuse risk while retaining buprenorphine's efficacy and safety. This prospective, open-label, multicenter trial compared preferences for buprenorphine and buprenorphine/naloxone in 53 opioid-dependent patients stabilized on buprenorphine. Buprenorphine was first administered at the patient's current dose (Days 1-2), followed by a direct switch to buprenorphine/naloxone (Days 3-5). Global satisfaction rates were high and similar between buprenorphine and buprenorphine/naloxone; however, patients preferred the tablet taste, size, and sublingual dissolution time of buprenorphine/naloxone. At the end of the study, 54% of patients preferred buprenorphine/naloxone, 31% preferred buprenorphine, and 15% had no preference; most patients (71%) wished to continue treatment with buprenorphine/naloxone. This study did not identify any impediments to a direct buprenorphine-to-buprenorphine/naloxone switch and revealed some characteristics that may facilitate treatment with buprenorphine/naloxone. (Author' s abstract)
Affiliation :
Centre Bizia, Bayonne. Email : jean-pierre.daulouede@wanadoo.fr
France. France.
France. France.
Cote :
Abonnement