Historique
Article de Périodique
HIV and HBV infection in intravenous drug addicts from Northeastern Italy (1987)
(Infections par HIV et HBV chez les toxicomanes par voie IV du nord-est de l'Italie)
Auteur(s) :
CONTE, D. ;
FERRONI, P. ;
LORINI G. P. ;
AIMO, G. P. ;
MANDELLI, C. ;
CESANA M. ;
BRUNELLI M. ;
BIGNOTTI, G. C. ;
BIANCHI, P. A. ;
ZANETTI, A. R.
Année
1987
Page(s) :
299-306
Langue(s) :
Anglais
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Résumé :
FRANÇAIS :
Evaluation dans 5 villes du Nord-Est de l'Italie. La prévalence de l'antigène HBs est de 13, 9%, significativement supérieure à la population contrôle, 41 de ces 42 patients étaient des porteurs chroniques. Dans près de la moitié des cas (51, 7%), il existait des anticorps anti-virus de l'hépatite B. Les autres marqueurs de l'hépatite B étaient reconnus dans la plupart des cas puisque seuls 38 sujets sur 302 ne possédaient aucun de ces marqueurs. La présence d'anticorps anti-HIV a été notée dans 70, 5% des cas, proportion significativement plus importante chez les sujets ayant des anti-corps anti-HBc comparée aux sujets n'ayant pas ce type d'anticorps. Les observations où il n'y avait pas d'infection par HIV ou HBV correspondaient à des sujets dont la toxicomanie était plus récente. Dans 56, 3% des cas des sujets HIV positifs, il existait une traduction symptomatique. Des variations géographiques étaient également observées entre ces 5 villes.
ENGLISH:
Three hundred and two intravenous drug addicts (IVDA) from five towns in Northeastern Italy were studied. Of the males, 37/249 (14.8%) were homosexuals and of the females, 29/53 (54.7%) were prostitutes; 118 (39.0%) were alcoholics. AST levels were abnormal in 31.876, ALT in45.7%, GTP in 36.4%, and bilirubin in 14.6%. The prevalence of HBsAg (13.9%) and HBeAg (21.4% of HBsAg positive) was significantly higher than in 2,983 controls (4.2% and 6.3%. p < .001 and p < .02, respectively). Of the HBsAg posi:ive subjects, 51.7% had anti-HDV antibodies. Among 260 HBsAg negative cases, 146 (56.2%) were anti-HBs and anti-HBc positive, 76 (29.2%) were anti-HBc positive and anti-HBs negative (25 anti-HBe positive and 51 anti-HBe negative), and 38 had no HBV markers. Anti-HIV ELISA positive subjects came to 70.5% (triplicate determination with absolute concordance) and Western blot analysis confirmed the results in 99.1% of ELISA positive and 100% of ELISA negative subjects. The prevalence of anti-HIV was significantly higher in anti-HBc positive than negative cases (p < .02), even excluding HBsAg positive subjects. Cases negative for HIV and HBV had a significantly lower median duration of drug abuse than those with past or present infection (36 vs 60 months, p < .001). HIV-related diseases were present in 56.3% of the cases (120/213; PGL in 94, ARC in 24, and AIDS in two). The absolute T4 + cell count correlated inversely with the prevalence and severity of HIV-related diseases-9/10 had less than 400 T4+ cells/ml (one PGL, seven ARC, and one AIDS), 33/47 had 400-800 T4+ cells/ml (27 PGL, five ARC, and one AIDS), and 25/40 had over 800 T4+ cells/ml (25 PGL). Geographical differences were observed in the distribution of the ratio between symptomatid infected cases.
Evaluation dans 5 villes du Nord-Est de l'Italie. La prévalence de l'antigène HBs est de 13, 9%, significativement supérieure à la population contrôle, 41 de ces 42 patients étaient des porteurs chroniques. Dans près de la moitié des cas (51, 7%), il existait des anticorps anti-virus de l'hépatite B. Les autres marqueurs de l'hépatite B étaient reconnus dans la plupart des cas puisque seuls 38 sujets sur 302 ne possédaient aucun de ces marqueurs. La présence d'anticorps anti-HIV a été notée dans 70, 5% des cas, proportion significativement plus importante chez les sujets ayant des anti-corps anti-HBc comparée aux sujets n'ayant pas ce type d'anticorps. Les observations où il n'y avait pas d'infection par HIV ou HBV correspondaient à des sujets dont la toxicomanie était plus récente. Dans 56, 3% des cas des sujets HIV positifs, il existait une traduction symptomatique. Des variations géographiques étaient également observées entre ces 5 villes.
ENGLISH:
Three hundred and two intravenous drug addicts (IVDA) from five towns in Northeastern Italy were studied. Of the males, 37/249 (14.8%) were homosexuals and of the females, 29/53 (54.7%) were prostitutes; 118 (39.0%) were alcoholics. AST levels were abnormal in 31.876, ALT in45.7%, GTP in 36.4%, and bilirubin in 14.6%. The prevalence of HBsAg (13.9%) and HBeAg (21.4% of HBsAg positive) was significantly higher than in 2,983 controls (4.2% and 6.3%. p < .001 and p < .02, respectively). Of the HBsAg posi:ive subjects, 51.7% had anti-HDV antibodies. Among 260 HBsAg negative cases, 146 (56.2%) were anti-HBs and anti-HBc positive, 76 (29.2%) were anti-HBc positive and anti-HBs negative (25 anti-HBe positive and 51 anti-HBe negative), and 38 had no HBV markers. Anti-HIV ELISA positive subjects came to 70.5% (triplicate determination with absolute concordance) and Western blot analysis confirmed the results in 99.1% of ELISA positive and 100% of ELISA negative subjects. The prevalence of anti-HIV was significantly higher in anti-HBc positive than negative cases (p < .02), even excluding HBsAg positive subjects. Cases negative for HIV and HBV had a significantly lower median duration of drug abuse than those with past or present infection (36 vs 60 months, p < .001). HIV-related diseases were present in 56.3% of the cases (120/213; PGL in 94, ARC in 24, and AIDS in two). The absolute T4 + cell count correlated inversely with the prevalence and severity of HIV-related diseases-9/10 had less than 400 T4+ cells/ml (one PGL, seven ARC, and one AIDS), 33/47 had 400-800 T4+ cells/ml (27 PGL, five ARC, and one AIDS), and 25/40 had over 800 T4+ cells/ml (25 PGL). Geographical differences were observed in the distribution of the ratio between symptomatid infected cases.
Affiliation :
Patologia Medica III, Istituto di Scienze Mediche, Italy