Historique
Article de Périodique
Limited stimulus generalization between delta-9-THC and diazepam in pigeons and gerbils (1988)
(Generalization limitée du stimulus induit par le delta-9-THC et le diazepam chez le pigeon et le mérione)
Auteur(s) :
TORBJORN, U. C. J. ;
HILTUNEN, A. J.
Année
1988
Page(s) :
328-331
Langue(s) :
Anglais
Refs biblio. :
21
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TETRAHYDROCANNABINOL
;
MECANISME D'ACTION
;
BENZODIAZEPINES
;
NEUROTRANSMETTEURS
;
VOIE D'ADMINISTRATION
;
MODELE ANIMAL
Résumé :
FRANÇAIS :
Des pigeons entrainés pour reconnaitre l'absence ou la présence de tetrahydrocannabinol, ont reçu du diazepam par voie intra-gastrique. Ils n'ont étendu la réponse induite par le THC au diazepam que dans une faible mesure.
ENGLISH:
Pigeons trained to discriminate between the presence and absence of delta9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6–30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. Two groups of gerbils trained to discriminate between the presence and absence of IP (intraperitoneally) injected benzodiazepine agonists (5.6 mg/kg of diazepam and Ro 11-3128, respectively) generally did not generalize the drug response to IP administered THC (5.6 and 17.5 mg/kg). In addition, substitution testing with the dopamine autoreceptor blocker (+)-3PPP yielded non-drug responding in the pigeons. Hence neither proposed structural similarity between 3-PPP and THC, nor purported anxiolytic activity by 3-PPP (see Introduction) matched the THC-induced stimulus effects. The data are discussed with reference to the specificity of the THC cue or stimulus.
Des pigeons entrainés pour reconnaitre l'absence ou la présence de tetrahydrocannabinol, ont reçu du diazepam par voie intra-gastrique. Ils n'ont étendu la réponse induite par le THC au diazepam que dans une faible mesure.
ENGLISH:
Pigeons trained to discriminate between the presence and absence of delta9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6–30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. Two groups of gerbils trained to discriminate between the presence and absence of IP (intraperitoneally) injected benzodiazepine agonists (5.6 mg/kg of diazepam and Ro 11-3128, respectively) generally did not generalize the drug response to IP administered THC (5.6 and 17.5 mg/kg). In addition, substitution testing with the dopamine autoreceptor blocker (+)-3PPP yielded non-drug responding in the pigeons. Hence neither proposed structural similarity between 3-PPP and THC, nor purported anxiolytic activity by 3-PPP (see Introduction) matched the THC-induced stimulus effects. The data are discussed with reference to the specificity of the THC cue or stimulus.
Affiliation :
Dept Psychol., Univ. Uppsala, S-751 04 Uppsala
Suède. Sweden.
Suède. Sweden.