Historique
Article de Périodique
Investigation of interference by nonsteroidal antiinflammatory drugs in urine tests for abused drugs (1990)
(Recherche sur les interférences produites par les anti-inflammatoires non-stéroïdiens lors des dépistages de drogues dans les urines)
Auteur(s) :
ROLLINS, D. E. ;
JENNISON, T. A. ;
JONES, G.
Année
1990
Page(s) :
602-606
Langue(s) :
Anglais
Refs biblio. :
14
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Clinical Chemistry, 1990, 36, (4), 602-606
Résumé :
FRANÇAIS :
Des études ayant suggéré que les anti-inflammatoires non-stéroïdiens peuvent donner lieu à de faux positifs dans les urines de toxicomanes, une étude a été réalisée sur 102 volontaires absorbant différents anti-inflammatoires non-stéroïdiens : deux ont eu des tests positifs au cannabis, il n'y a eu aucun faux positif pour les benzodiazépines.
ENGLISH:
Anecdotal and uncontrolled studies have suggested that nonsteroidal anti-inflammatory drugs produce false-positive results in immunoassay urine tests for some drugs of abuse. This study was performed in 60 volunteers who took ibuprofen as either a single 400-mg dose, or 200 mg three times a day, or 400 mg three times a day, and in 42 patients taking ibuprofen, naproxyn, or fenoprofen in therapeutic regimens for more than 30 days. Of the 510 urines collected from 102 individuals during these dosage regimens, two gave false-positive tests for cannabinoid by enzyme-mediated immunoassay (EMIA), one after 1200 mg of ibuprofen in three divided doses for one day and one in a patient taking naproxyn on a chronic basis; none was falsely positive for benzodiazepines. Two urines were false-positive for barbiturates by fluorescence polarization immunoassay (FPIA), one in a patient taking ibuprofen and one in a patient taking naproxyn. These data, collected prospectively, demonstrate the small likelihood of a false-positive immunoassay test result for cannabinoids, benzodiazepines, or barbiturates after the acute or chronic ingestion of ibuprofen, or after the chronic ingestion of naproxyn or fenoprofen. (Extrat of the document)
Des études ayant suggéré que les anti-inflammatoires non-stéroïdiens peuvent donner lieu à de faux positifs dans les urines de toxicomanes, une étude a été réalisée sur 102 volontaires absorbant différents anti-inflammatoires non-stéroïdiens : deux ont eu des tests positifs au cannabis, il n'y a eu aucun faux positif pour les benzodiazépines.
ENGLISH:
Anecdotal and uncontrolled studies have suggested that nonsteroidal anti-inflammatory drugs produce false-positive results in immunoassay urine tests for some drugs of abuse. This study was performed in 60 volunteers who took ibuprofen as either a single 400-mg dose, or 200 mg three times a day, or 400 mg three times a day, and in 42 patients taking ibuprofen, naproxyn, or fenoprofen in therapeutic regimens for more than 30 days. Of the 510 urines collected from 102 individuals during these dosage regimens, two gave false-positive tests for cannabinoid by enzyme-mediated immunoassay (EMIA), one after 1200 mg of ibuprofen in three divided doses for one day and one in a patient taking naproxyn on a chronic basis; none was falsely positive for benzodiazepines. Two urines were false-positive for barbiturates by fluorescence polarization immunoassay (FPIA), one in a patient taking ibuprofen and one in a patient taking naproxyn. These data, collected prospectively, demonstrate the small likelihood of a false-positive immunoassay test result for cannabinoids, benzodiazepines, or barbiturates after the acute or chronic ingestion of ibuprofen, or after the chronic ingestion of naproxyn or fenoprofen. (Extrat of the document)
Affiliation :
Ctr Human Toxicol., Univ. Utah, 417 Wakara Way, Salt Lake City, UT 84108
Etats-Unis. United States.
Etats-Unis. United States.