Historique
Article de Périodique
Psychotogenic drug use and neuroleptic response (1990)
Auteur(s) :
BOWERS, M. B. ;
MAZURE, C. M. ;
NELSON, J. C. ;
JATLOW P. I.
Année
1990
Page(s) :
81-85
Langue(s) :
Anglais
Refs biblio. :
18
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
LSD
;
NEUROLEPTIQUES
;
TRAITEMENT
;
DIAGNOSTIC
;
ETUDE CLINIQUE
;
PSYCHOSE
Thésaurus géographique
ETATS-UNIS
Résumé :
FRANÇAIS :
Les psychotiques mâles ayant déjà utilisé des drogues psychogènes ont une réponse plus faible au traitement neuroleptique. L'abus de cannabis, LSD, etc... peut aggraver leur psychose, voire déclencher des troubles psychologiques. Le double diagnostic de psychose et de toxicomanie permet d'adapter le traitement neuroleptique.
ENGLISH :
When fixed doses of haloperidol or perphenazine were used in two separate studies, we found that psychotic males with a prior history of psychotogenic drug use had a poorer early neuroleptic response even in the early stages of their psychotic disorder than psychotic males who had not previously used significant amounts of psychotogenic drugs. Relative neuroleptic refractoriness may be characteristic of some dual diagnosis patients at the beginning of their illness. Antecedent psychotogenic drug use may contribute to the development of psychosis and to relative neuroleptic refractoriness by means of effects upon dopaminergic mechanisms. (Author's abstract)
Les psychotiques mâles ayant déjà utilisé des drogues psychogènes ont une réponse plus faible au traitement neuroleptique. L'abus de cannabis, LSD, etc... peut aggraver leur psychose, voire déclencher des troubles psychologiques. Le double diagnostic de psychose et de toxicomanie permet d'adapter le traitement neuroleptique.
ENGLISH :
When fixed doses of haloperidol or perphenazine were used in two separate studies, we found that psychotic males with a prior history of psychotogenic drug use had a poorer early neuroleptic response even in the early stages of their psychotic disorder than psychotic males who had not previously used significant amounts of psychotogenic drugs. Relative neuroleptic refractoriness may be characteristic of some dual diagnosis patients at the beginning of their illness. Antecedent psychotogenic drug use may contribute to the development of psychosis and to relative neuroleptic refractoriness by means of effects upon dopaminergic mechanisms. (Author's abstract)
Affiliation :
Yale University School of Medicine New Haven, CT, USA