Historique
Périodique
Effects of terminating chronic phencyclidine on schedule-controlled behavior in rats
(Effet d'une administration chronique de phencyclidine sur le conditionnement opérant chez le rat)
Auteur(s) :
MASSEY, B. W. ;
WESSINGER W. D.
Année
1990
Langue(s) :
Anglais
ISBN :
0091-3057
Refs biblio. :
16
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Pharmacology, Biochemistry and Behavior, 1990, 36, 117-121
Résumé :
FRANÇAIS :
Un symptôme de sevrage physique peut agir comme renforçateur de la consommation du toxique. Ce cas étudié avec les opiacés est valable aussi pour la PCP. Les auteurs travaillent sur 6 rats soumis à un conditionnement opérant à la prise de nourriture et étudient l'influence d'une administration aiguë ou chronique de PCP sur ce conditionnement.
ENGLISH :
Six rats were trained to respond under a multiple fixed-ratio 30, fixed-interval 3-min schedule for food presentation. Acute administration of phencyclidine (0, 1-3, 2 mg/kg, IP) produced decreases in fixed-ratio response rates at doses above 0,3 mg/kg, but fixed-interval response rates were only decreased at the highest dose. However, the pattern of fixed-interval responding (as evidenced by quarter-life values) was affected at doses above 0,3 mg/kg. Osmotic minipumps were implanted, SC, with infused saline (2 rats) or phencyclidine (4 rats, 100 mg/kg/day) for 10 days, and then removed. Daily behavioral sessions were conducted during infusions and for 10 days afterwards. The effects of phencyclidine infusions on fixed-ratio responding were variable. Fixed-interval response rate and quarter-life values were only modestly affected during drug infusion. All three parameters were markedly affected upon cessation of chronic phencyclidine dosing, but there did not appear to be differential effects between the schedule components. No effects on responding were observed during or after saline infusions. (Author's abstract)
Un symptôme de sevrage physique peut agir comme renforçateur de la consommation du toxique. Ce cas étudié avec les opiacés est valable aussi pour la PCP. Les auteurs travaillent sur 6 rats soumis à un conditionnement opérant à la prise de nourriture et étudient l'influence d'une administration aiguë ou chronique de PCP sur ce conditionnement.
ENGLISH :
Six rats were trained to respond under a multiple fixed-ratio 30, fixed-interval 3-min schedule for food presentation. Acute administration of phencyclidine (0, 1-3, 2 mg/kg, IP) produced decreases in fixed-ratio response rates at doses above 0,3 mg/kg, but fixed-interval response rates were only decreased at the highest dose. However, the pattern of fixed-interval responding (as evidenced by quarter-life values) was affected at doses above 0,3 mg/kg. Osmotic minipumps were implanted, SC, with infused saline (2 rats) or phencyclidine (4 rats, 100 mg/kg/day) for 10 days, and then removed. Daily behavioral sessions were conducted during infusions and for 10 days afterwards. The effects of phencyclidine infusions on fixed-ratio responding were variable. Fixed-interval response rate and quarter-life values were only modestly affected during drug infusion. All three parameters were markedly affected upon cessation of chronic phencyclidine dosing, but there did not appear to be differential effects between the schedule components. No effects on responding were observed during or after saline infusions. (Author's abstract)
Affiliation :
Dept Pharmacol. Toxicol., Univ. Arkansas Med. Sci., 4301 W. Markham st, Little Rock, AR 72205
Etats-Unis. United States.
Etats-Unis. United States.