Historique
Article de Périodique
Effects of antihistaminics on nalexone-induced withdrawal in morphine-dependent mice (1990)
(Effets des antihistaminiques sur le sevrage par naloxone chez les souris dépendantes à la morphine)
Auteur(s) :
LEZA, J. C. ;
LIZASOAIN, I. ;
LORENZO, P.
Année
1990
Page(s) :
106-111
Langue(s) :
Anglais
Refs biblio. :
37
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Résumé :
FRANÇAIS :
L'influence des antihistaminiques (antagonsites de H1 et H2) sur le sevrage par naloxone est testée sur l'activité locomotrice de la souris (sauts, secousses, tremblements...) en fonction des doses et du temps.
ENGLISH:
Some histamine H1 (tripelennamine, diphenhydramine and cyclizine) and H2 (ranitidine and cimetidine) antagonists (1 and 10 mg/kg) were administered to morphine — dependent mice to evaluate the changes on naloxone-induced abstinence syndrome. When antihistaminics were administered 30 min before naloxone (1 mg/kg) on day 4 of morphine addiction, the two doses of the three H1 antagonists and the higher dose of ranitidine inhibited shaking behavior. Furthermore, the two doses of tripelennamine and the higher dose of diphenhydramine, cyclizine and cimetidine enhanced jumping behavior. When antihistaminics were administered chronically (during the 4 days of morphine addiction), tripelennamine, cyclizine and ranitidine (all at 10 mg/kg) inhibited shaking behavior. The three H1 antihistaminics used enhanced the number of jumps per mouse whereas ranitidine decreased this response. No significant changes were found in the rest of the withdrawal symptoms after the antihistaminics were administered. The participation of serotonergic and catecholaminergic mechanisms is discussed.
L'influence des antihistaminiques (antagonsites de H1 et H2) sur le sevrage par naloxone est testée sur l'activité locomotrice de la souris (sauts, secousses, tremblements...) en fonction des doses et du temps.
ENGLISH:
Some histamine H1 (tripelennamine, diphenhydramine and cyclizine) and H2 (ranitidine and cimetidine) antagonists (1 and 10 mg/kg) were administered to morphine — dependent mice to evaluate the changes on naloxone-induced abstinence syndrome. When antihistaminics were administered 30 min before naloxone (1 mg/kg) on day 4 of morphine addiction, the two doses of the three H1 antagonists and the higher dose of ranitidine inhibited shaking behavior. Furthermore, the two doses of tripelennamine and the higher dose of diphenhydramine, cyclizine and cimetidine enhanced jumping behavior. When antihistaminics were administered chronically (during the 4 days of morphine addiction), tripelennamine, cyclizine and ranitidine (all at 10 mg/kg) inhibited shaking behavior. The three H1 antihistaminics used enhanced the number of jumps per mouse whereas ranitidine decreased this response. No significant changes were found in the rest of the withdrawal symptoms after the antihistaminics were administered. The participation of serotonergic and catecholaminergic mechanisms is discussed.
Affiliation :
Dept. Farmacol., Fac. Med., Univ. Complutense, E 28040 Madrid
Espagne. Spain.
Espagne. Spain.