Historique
Article de Périodique
Naloxone induces miosis in normal subjects (1990)
(La naloxone induit un myosis chez le sujet normal)
Auteur(s) :
LOIMER, N. ;
SCHMID, R. ;
GRUNBERGER, J. ;
LINZMAYER, L.
Année
1990
Page(s) :
282-283
Langue(s) :
Anglais
Refs biblio. :
7
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Résumé :
FRANÇAIS :
La naloxone, un antagoniste opiacé pur, induit contrairement à l'opinion généralement admise un myosis serré chez le sujet sain, non opio-dépendant. Ceci peut être la conséquence d'un effet agoniste partiel ou d'une libération locale d'endorphines consécutive à la fixation de la naloxone sur les récepteurs spécifiques.
ENGLISH:
In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0, 4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0, 4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response. (Author's abstract)
La naloxone, un antagoniste opiacé pur, induit contrairement à l'opinion généralement admise un myosis serré chez le sujet sain, non opio-dépendant. Ceci peut être la conséquence d'un effet agoniste partiel ou d'une libération locale d'endorphines consécutive à la fixation de la naloxone sur les récepteurs spécifiques.
ENGLISH:
In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0, 4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0, 4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response. (Author's abstract)
Affiliation :
Psychiat. Univ. Klin. Wien, Waehringer Guertel 18-20, 1090 Vienna
Autriche. Austria.
Autriche. Austria.