Historique
Périodique
Détermination of cocaine and its metabolites in parotid saliva, plasma, urine and amniotic fluid in pregnant and non pregnant rats
(Identification de la cocaïne et de ses métabolites dans la salive parotidienne, le plasma, l'urine et le liquide amniotique chez les rats femelles gravides et non-gravides)
Auteur(s) :
FERKO, A. P. ;
BARBIERI, E. J. ;
DIGREGORIO G. J. ;
RUCH, E. K.
Année
1991
Langue(s) :
Anglais
ISBN :
0193-0818
Refs biblio. :
15
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Research Communications in Substances of Abuse, 1991, 12, (1-2), 1-17
Résumé :
FRANÇAIS :
La pharmacocinétique de la cocaïne chez des femelles de rats gravides comparée à celles non gravides, révèle la présence de cocaïne et de son métabolite la benzoylecgonine dans le plasma, la salive parotidienne et l'urine de tous les animaux examinés, ainsi que dans le liquide amniotique des femelles gravides.
ENGLISH :
Parotid saliva, blood, and urine were obtained at various time periods from anesthetized pregnant and nonpregnant female Sprague-Dawley rats following intravenous administration of cocaine hydrochloride in doses of 0.5, 1 and 2 mg / kg ; in addition, 60 min after cocaine administration amniotic fluid was collected from pregnant animals. Cocaine and benzoylecgonine were found in the urine 60 min after the injection of cocaine. In the pregnant rats the level of cocaine present in the urine and amniotic fluid correlated with the various doses of cocaine administered. Plasma cholinesterase activity measured in the nonpregnant and pregnant rats was found to be similar. This study indicates that the pharmacokinetics of cocaine are similar in nonpregnant and pregnant rats. (Extract from author's abstract)
La pharmacocinétique de la cocaïne chez des femelles de rats gravides comparée à celles non gravides, révèle la présence de cocaïne et de son métabolite la benzoylecgonine dans le plasma, la salive parotidienne et l'urine de tous les animaux examinés, ainsi que dans le liquide amniotique des femelles gravides.
ENGLISH :
Parotid saliva, blood, and urine were obtained at various time periods from anesthetized pregnant and nonpregnant female Sprague-Dawley rats following intravenous administration of cocaine hydrochloride in doses of 0.5, 1 and 2 mg / kg ; in addition, 60 min after cocaine administration amniotic fluid was collected from pregnant animals. Cocaine and benzoylecgonine were found in the urine 60 min after the injection of cocaine. In the pregnant rats the level of cocaine present in the urine and amniotic fluid correlated with the various doses of cocaine administered. Plasma cholinesterase activity measured in the nonpregnant and pregnant rats was found to be similar. This study indicates that the pharmacokinetics of cocaine are similar in nonpregnant and pregnant rats. (Extract from author's abstract)
Affiliation :
Hahnemann Univ., Sch. Med., Philadelphia, PA 19102
Etats-Unis. United States.
Etats-Unis. United States.