Historique
Article de Périodique
Skeletal muscle as an alternative specimen for alcohol and drug analysis (1991)
(Le muscle squelettique comme moyen alternatif de dépistage de l'alcool et des drogues)
Auteur(s) :
GARRIOTT, J. C.
Année
1991
Page(s) :
60-69
Langue(s) :
Anglais
Refs biblio. :
13
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Résumé :
FRANÇAIS :
La concentration de drogue dans le muscle varie d'un facteur 1 à 6,5 par rapport à celle du produit dans le sang, et dépend du temps entre l'ingestion et la mort, et de la nature de la drogue. Pour la plupart des drogues courantes elle est voisine de 1. Le muscle peut être proposé comme échantillon post-mortem pour les dépistages toxicologiques.
ENGLISH :
In a random group of medical examiner cases, muscle tissue, as well as blood and vitreous humor, was analyzed for ethyl alcohol, and the results were compared. When the blood concentration was greater than 0.10 g/dL, the muscle to blood ratio was 1.00 or less (average 0.94), and when the blood concentration was less than 0.10 g/dL, this ratio was greater than 1.00 (average 1.48). The author proposes that this ratio is dependent upon the time course of absorption and distribution, as has been observed for vitreous humor, but with a more rapid equilibration. Muscle tissue was also analyzed in another group of cases found to be positive for one or more drugs in blood. The concentrations of the drugs in muscle varied from none detected to 6.5 times those in blood and seemed to be dependent on the time course between ingestion and death, as well as on the nature of the drug. For most common basic drugs, the ratios were often near unity. Muscle is proposed as a useful alternative specimen to postmortem blood.
La concentration de drogue dans le muscle varie d'un facteur 1 à 6,5 par rapport à celle du produit dans le sang, et dépend du temps entre l'ingestion et la mort, et de la nature de la drogue. Pour la plupart des drogues courantes elle est voisine de 1. Le muscle peut être proposé comme échantillon post-mortem pour les dépistages toxicologiques.
ENGLISH :
In a random group of medical examiner cases, muscle tissue, as well as blood and vitreous humor, was analyzed for ethyl alcohol, and the results were compared. When the blood concentration was greater than 0.10 g/dL, the muscle to blood ratio was 1.00 or less (average 0.94), and when the blood concentration was less than 0.10 g/dL, this ratio was greater than 1.00 (average 1.48). The author proposes that this ratio is dependent upon the time course of absorption and distribution, as has been observed for vitreous humor, but with a more rapid equilibration. Muscle tissue was also analyzed in another group of cases found to be positive for one or more drugs in blood. The concentrations of the drugs in muscle varied from none detected to 6.5 times those in blood and seemed to be dependent on the time course between ingestion and death, as well as on the nature of the drug. For most common basic drugs, the ratios were often near unity. Muscle is proposed as a useful alternative specimen to postmortem blood.
Affiliation :
Bexar County Medical Examiner's Office, Regional Crime Laboratory, San Antonio, TX, USA