Historique
Périodique
Cocaine and pregnancy : clinical and methodologic issues
(Cocaine et grossesse : données cliniques et méthodologiques)
Auteur(s) :
CHASNOFF I. J.
Année
1991
Langue(s) :
Anglais
ISBN :
0095-5108
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
COCAINE
;
CONSOMMATION
;
MERE
;
ENFANT D'USAGER
;
FOETUS
;
GROSSESSE
;
TOXICITE
;
MALFORMATION
;
TRAITEMENT
;
PRISE EN CHARGE
Note générale :
Clinics in Perinatology, 1991, 18, 113-123
Résumé :
FRANÇAIS :
Les différentes études cliniques ont permis de bien connaître les facteurs de risque et la pathologie des grossesses chez les cocaïnomanes. L'activité vasoconstrictrice de la cocaïne entraîne un dysfonctionnement placentaire qui augmente le risque de retard de croissance, de malformations foetales ainsi qu'une pathologie neurologique. Il faudrait toutefois affiner les méthodes analytiques pour mieux évaluer les effets additionnels et interactionnels des facteurs sociaux.
ENGLISH :
Although many of the clinical studies of cocaine use in pregnancy completed thus far have suffered from the methodologic issues discussed here, they have been of great value in defining key risk factors and general clinical outcome. With the information now available, it appears safe to conclude that placental dysfunction due to cocaine's vasoconstrictive activity increases risk for intrauterine growth retardation and prematurity ; fetal disruption due to acute cocaine-induced vascular compromise places the fetus at risk for structural anomalies ; and neurotoxicity due to cocaine's action at the postsynaptic junction places the infant at risk for neurobehavioral abnormalities. There are now needed more sophisticated analytic techniques that can consider the additive and interactive effects of demographic and lifestyle characteristics that place the cocaine-using pregnant woman and her child at risk. (Author's abstract)
Les différentes études cliniques ont permis de bien connaître les facteurs de risque et la pathologie des grossesses chez les cocaïnomanes. L'activité vasoconstrictrice de la cocaïne entraîne un dysfonctionnement placentaire qui augmente le risque de retard de croissance, de malformations foetales ainsi qu'une pathologie neurologique. Il faudrait toutefois affiner les méthodes analytiques pour mieux évaluer les effets additionnels et interactionnels des facteurs sociaux.
ENGLISH :
Although many of the clinical studies of cocaine use in pregnancy completed thus far have suffered from the methodologic issues discussed here, they have been of great value in defining key risk factors and general clinical outcome. With the information now available, it appears safe to conclude that placental dysfunction due to cocaine's vasoconstrictive activity increases risk for intrauterine growth retardation and prematurity ; fetal disruption due to acute cocaine-induced vascular compromise places the fetus at risk for structural anomalies ; and neurotoxicity due to cocaine's action at the postsynaptic junction places the infant at risk for neurobehavioral abnormalities. There are now needed more sophisticated analytic techniques that can consider the additive and interactive effects of demographic and lifestyle characteristics that place the cocaine-using pregnant woman and her child at risk. (Author's abstract)
Affiliation :
Natl Assoc. Perinat. Addict. Res. (NAPARE), 11 E. Hubbard st., Chicago IL 60611
Etats-Unis. United States.
Etats-Unis. United States.