Historique
Périodique
Heroin addiction: neurobiology, pharmacology and policy
(Dépendance à l'héroïne: neurobiologie, pharmacologie et politique)
Auteur(s) :
GOLDSTEIN, A.
Année
1991
Langue(s) :
Anglais
ISBN :
0279-1072
Refs biblio. :
32
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of Psychoactive Drugs, 1991, 23, (2), 123-133
Résumé :
FRANÇAIS :
La toxicomanie considérée en tant que "maladie métabolique" est une entité propre; c'est une anomalie neurochimique du système des opiacés endogènes. Le traitement à la méthadone est un palliatif du déficit neurohormonal. Il faut développer son utilisation ainsi que celles des nouvelles pharmacothérapies.
ENGLISH :
The neurobiology of drug addiction is being clarified. Research is revealing the anatomic pathways of primary drug reinforcement (reward) in the brain and the molecular architecture of the receptors on which addictive drugs act. All addictive drugs mimic (or occasionally block) the actions of some neurotransmitter; in the case of heroin or methadone an endogenous opioid, probably beta-endorphin. The groundwork is being laid for understanding Dole and Nyswander's "metabolic disease" concept as a concrete neurochemical abnormality of the endogenous opioid system. Thus, a stronger basis is developing for regarding methadone maintenance as a means of replacing a neurohormonal deficiency. Three practical conclusions that can be drawn from this model are: (1) methadone dosage must be adequate (never less than 50-80mg) ; (2) it should be more widely accepted that some patients may require lifelong methadone maintenance; and (3) longer-acting, better stabilizing methadone congeners, such as LAAM and its metabolites, should be brought into general use. (Author's abstract)
La toxicomanie considérée en tant que "maladie métabolique" est une entité propre; c'est une anomalie neurochimique du système des opiacés endogènes. Le traitement à la méthadone est un palliatif du déficit neurohormonal. Il faut développer son utilisation ainsi que celles des nouvelles pharmacothérapies.
ENGLISH :
The neurobiology of drug addiction is being clarified. Research is revealing the anatomic pathways of primary drug reinforcement (reward) in the brain and the molecular architecture of the receptors on which addictive drugs act. All addictive drugs mimic (or occasionally block) the actions of some neurotransmitter; in the case of heroin or methadone an endogenous opioid, probably beta-endorphin. The groundwork is being laid for understanding Dole and Nyswander's "metabolic disease" concept as a concrete neurochemical abnormality of the endogenous opioid system. Thus, a stronger basis is developing for regarding methadone maintenance as a means of replacing a neurohormonal deficiency. Three practical conclusions that can be drawn from this model are: (1) methadone dosage must be adequate (never less than 50-80mg) ; (2) it should be more widely accepted that some patients may require lifelong methadone maintenance; and (3) longer-acting, better stabilizing methadone congeners, such as LAAM and its metabolites, should be brought into general use. (Author's abstract)
Affiliation :
735 Dolores st, Stanford, CA 94305
Etats-Unis. United States.
Etats-Unis. United States.