Effects of food deprivation on subjective effects and self-administration of marijuana in humans (1991)

FRANÇAIS :
Un protocole complexe associant marijuana et cigarettes "placebo" après des épisodes de jeûne et d'alimentation normale, étudie les effets cardio-vasculaires, thymiques, métaboliques ainsi que la consommation de marijuana d'un petit groupe de 4 hommes et 1 femme. Les résultats montrent que les effets de la marijuana ne sont pas affectés par la prise ou non de nourriture et que les différences quantitatives de consommation du produit ne sont pas liées au jeûne.
ENGLISH :
The effects of fasting on the intake and subjective effects of marijuana were studied in five marijuana smokers. A within-subjects desing was used in which subjects smoked either active (0.8 and 306% THC) or placebo (0.0% THC) marijuana after eating normally or after fasting for 24hr. Subjective and physiological measures (i.e., carbon monoxide level and heart rate) were assesed before and 5, 20, and 60 min. Dose dependent effects of marijuana, such as elevated heart rate and "high" ratings, were observed during the sampling period, but these effects of marijuana were not affected by the feeding manipulation. Subjects varied widely in their marijuana self administration, but self-administration was not systematically affected by fasting. We conclude that an acute period of food deprivation does not affect the mood altering effects of different potencies of marijuana. We could not adequately demonstrate whether fasting increases the reinforcing efficacy of marijuana, since selfadministration rate of active marijuana did not exceed that of placebo marijuana self-administration.