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Changes in benzodiazépine-receptor activity modify morphine withdrawal syndrome in mice
(Des changements d'activité des récepteurs des benzodiazépines entrainent des modifications du syndrome de sevrage chez la souris.)
Auteur(s) :
VALVERDE O. ;
MICO, J. A. ;
MALDONADO, R. ;
GIBERT-RAHOLA, J.
Année
1992
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
46
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
BENZODIAZEPINES
;
OPIACES
;
AGONISTE
;
ANTAGONISTE
;
RECEPTEUR
;
SYNDROME DE SEVRAGE
Note générale :
Drug and Alcohol Dependence, 1992, 30, 293-300
Résumé :
FRANÇAIS :
Différents ligands des récepteurs des benzodiazépines (agoniste, antagoniste, agoniste partiel ou agoniste inverse partiel) sont administrés à des souris morphinodépendantes, 30 minutes avant l'induction du sevrage par la naltrexone. L'étude des signes de sevrage permet de penser que les agonistes et agonistes partiels (flunitrazepam et RO 16-6028) atténuent la sévérité du syndrome de sevrage.
ENGLISH :
The effects of different benzodiazepine-receptor ligands on morphine withdrawal were studied: a benzodiazepine agonist, flunitrazepam; a benzodiazepine antagonist, flumazenil: a partial inverse benzodiazepine agonist. RO 15-4513, and a partial benzodiazepine agonist, RO 16-6028. Benzodiazepine-ligands were administered i.p. 30 min before naloxone-induced morphine withdrawal syndrome. Our results show that the activation of the benzodiazepine receptor by agonists or high doses of partial agonists decreases jumping and increases wet dog shake behaviour, while the antagonists or the partial inverse agonists enhance jumping and decrease wet dog shakes. These modifications could be interpreted as an attenuation in the severity of the morphine withdrawal syndrome by benzodiazepine agonists. (Extract from author's abstract)
Différents ligands des récepteurs des benzodiazépines (agoniste, antagoniste, agoniste partiel ou agoniste inverse partiel) sont administrés à des souris morphinodépendantes, 30 minutes avant l'induction du sevrage par la naltrexone. L'étude des signes de sevrage permet de penser que les agonistes et agonistes partiels (flunitrazepam et RO 16-6028) atténuent la sévérité du syndrome de sevrage.
ENGLISH :
The effects of different benzodiazepine-receptor ligands on morphine withdrawal were studied: a benzodiazepine agonist, flunitrazepam; a benzodiazepine antagonist, flumazenil: a partial inverse benzodiazepine agonist. RO 15-4513, and a partial benzodiazepine agonist, RO 16-6028. Benzodiazepine-ligands were administered i.p. 30 min before naloxone-induced morphine withdrawal syndrome. Our results show that the activation of the benzodiazepine receptor by agonists or high doses of partial agonists decreases jumping and increases wet dog shake behaviour, while the antagonists or the partial inverse agonists enhance jumping and decrease wet dog shakes. These modifications could be interpreted as an attenuation in the severity of the morphine withdrawal syndrome by benzodiazepine agonists. (Extract from author's abstract)
Affiliation :
Dpet Neurosci. , Lab. Neuropsychopharm., Sch. Med., Pl. Fragela 11003 Cadiz
Espagne. Spain.
Espagne. Spain.