Historique
Périodique
Discriminative stimulus properties of cocaine, alone and in combination with buprenorphine, morphine and naltrexone
(Propriétés stimulantes discriminatoires de la cocaïne, seule et en association avec la buprénorphine, la morphine et la naltrexone)
Auteur(s) :
DYKSTRA L.A. ;
DOTY P. ;
JOHNSON, A. B. ;
PICKER M.J.
Année
1992
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
22
Domaine :
Drogues illicites
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
BUPRENORPHINE
;
COCAINE
;
INTERACTION CHIMIQUE
;
ANTAGONISTE
;
AGONISTE
;
CONDITIONNEMENT
Note générale :
Drug and Alcohol Dependence, 1992, 30, 227-234
Résumé :
FRANÇAIS :
Le but est d'étudier l'action de la buprénorphine sur les effets de renforcement de la cocaïne, sur des rats conditionnés à discriminer la cocaïne. L'expérience montre en fait, que la buprénorphine ne produit que de petites altérations des effets de stimulus discriminatoire de la cocaïne, et que la nature de ces altérations dépend de la dose de cocaïne administrée.
ENGLISH :
Rats were trained to discriminate a dose of 10.0 mg/kg cocaine from saline. During substitution tests, both cocaine (5.6-10.0 mg/kg) and d-amphetamine (1.0-3.0 mg/kg) produced greater than 80% responding on the cocaine-appropriate lever. In contrast, buprenorphine (0.03-0.56 mg/kg) morphine (0.3-10.0 mg/kg) and naltrexone (1.0-10.0 mg/kg) failed to substitute for the cocaine stimulus, up to doses that substantially decreased rate of responding. When the cocaine dose-effect curve was redetermined in the presence of selected doses of buprenorphine, the amount of cocaine-appropriate responding following a low dose of cocaine (1.0 mg/kg) was increased slightly whereas cocaine-appropriate responding following higher doses of cocaine (3.0 and 5.6 mg/kg) was reduced slightly. Responding following the training dose of cocaine (10.0 mg/kg) was not changed. These results indicate that buprenorphine produced only small alterations in cocaine's discriminative stimulus effects and that the nature of these alterations differed depending on the dose of cocaine examined. (Author's abstract)
Le but est d'étudier l'action de la buprénorphine sur les effets de renforcement de la cocaïne, sur des rats conditionnés à discriminer la cocaïne. L'expérience montre en fait, que la buprénorphine ne produit que de petites altérations des effets de stimulus discriminatoire de la cocaïne, et que la nature de ces altérations dépend de la dose de cocaïne administrée.
ENGLISH :
Rats were trained to discriminate a dose of 10.0 mg/kg cocaine from saline. During substitution tests, both cocaine (5.6-10.0 mg/kg) and d-amphetamine (1.0-3.0 mg/kg) produced greater than 80% responding on the cocaine-appropriate lever. In contrast, buprenorphine (0.03-0.56 mg/kg) morphine (0.3-10.0 mg/kg) and naltrexone (1.0-10.0 mg/kg) failed to substitute for the cocaine stimulus, up to doses that substantially decreased rate of responding. When the cocaine dose-effect curve was redetermined in the presence of selected doses of buprenorphine, the amount of cocaine-appropriate responding following a low dose of cocaine (1.0 mg/kg) was increased slightly whereas cocaine-appropriate responding following higher doses of cocaine (3.0 and 5.6 mg/kg) was reduced slightly. Responding following the training dose of cocaine (10.0 mg/kg) was not changed. These results indicate that buprenorphine produced only small alterations in cocaine's discriminative stimulus effects and that the nature of these alterations differed depending on the dose of cocaine examined. (Author's abstract)
Affiliation :
Dept Psychol., Univ. N. Carolina, Chapel Hill, NC 27599-3270
Etats-Unis. United States.
Etats-Unis. United States.