Historique
Périodique
Ammestic effects of intravenous diazepam in healthy young men
(Influence du diazépam par voie intraveineuse sur la mémoire de sujets jeunes et sains)
Auteur(s) :
ANTHENELLI, R. M. ;
MONTEIRO, M. G. ;
BLUNT B. ;
SCHUCKIT, M. A.
Année
1992
Langue(s) :
Anglais
ISBN :
0095-2990
Refs biblio. :
28
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Note générale :
American Journal of Drug and Alcohol Abuse, 1991, 17, (2), 129-136
Résumé :
FRANÇAIS :
Cette étude évalue les altérations de la mémoire après injection de diazépam à 103 sujets non dépendants. Les résultats suggèrent que les sujets abusant des benzodiazépines peuvent connaître des défaillances importantes de la mémoire.
ENGLISH :
Changes in a test of memory performance were evaluated in 103 healthy young men after challenges with placebo and two different doses of intravenous diazepam (0.12 and 0.20 mg/kg). Both diazepam doses significantly impaired free recall in a dose-dependent manner. Within each dose challenge there was no significant correlation between the average serum diazepam or desmethyldiazepam levels and the average number of words recalled across the time points. The data expand our current understanding of the amnestic effects of benzodiazepines and suggest that patients abusing these drugs in large doses may develop profound degrees of memory impairment. (Author's abstract)
Cette étude évalue les altérations de la mémoire après injection de diazépam à 103 sujets non dépendants. Les résultats suggèrent que les sujets abusant des benzodiazépines peuvent connaître des défaillances importantes de la mémoire.
ENGLISH :
Changes in a test of memory performance were evaluated in 103 healthy young men after challenges with placebo and two different doses of intravenous diazepam (0.12 and 0.20 mg/kg). Both diazepam doses significantly impaired free recall in a dose-dependent manner. Within each dose challenge there was no significant correlation between the average serum diazepam or desmethyldiazepam levels and the average number of words recalled across the time points. The data expand our current understanding of the amnestic effects of benzodiazepines and suggest that patients abusing these drugs in large doses may develop profound degrees of memory impairment. (Author's abstract)
Affiliation :
VA Med. Ctr, 3350 La Jolla Village dr., San Diego, CA 92161
Etats-Unis. United States.
Etats-Unis. United States.