Historique
Périodique
The intravenous self-administration of antihistaminics by rhesus monkeys
(L'autoadministration intraveineuse d'antihistaminiques chez des singes rhésus)
Auteur(s) :
BEARDSLEY, P. M. ;
BALSTER, R. L.
Année
1992
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
35
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
AUTOADMINISTRATION
;
ANTIHISTAMINIQUES
;
MODELE ANIMAL
;
MECANISME D'ACTION
Note générale :
Drug and Alcohol Dependence, 1992, 30, 117-126
Résumé :
FRANÇAIS :
Sur des rats préentrainés à l'autoadministration de cocaïne, on teste l'autoadministration de différents antihistaminiques. Tous les singes testés s'autoadministrent la tripélennamine et la chlorphéniramine. Aucun ne s'administre la phényltoloxamine, la cimétidine et l'hydroxyzine. Un seul s'administre la pyrilamine, mais à dose élevée. Ceci illustre les différences entre les antagonistes H1 et leur potentiel d'autoadministration, et suggère que leurs propriétés analogues de stimulants, quand elles existent, peuvent compléter l'effet de renforcement.
ENGLISH :
Rhesus monkeys were trained to lever press for infusions of cocaine during daily, 1h experimental sessions. Following stabilization of the cocaine-maintened baselines, various antihistamines were substituted for cocaine. The results indicated that all monkeys tested self-administered tripelennamine and chlorpheniramine. One monkey of the four self-administered pyrilamine, but only at a single (300micro g./kg)high dose. Phenyltoloxamine, cimetidine and hydroxyzine were not self-administered. These results further illuminate differences amongst H1 antagonists in their potential for self-administration and, suggest that stimulant-like properties may help mediate their reinforcing effects when present. (Extract from author's abstract)
Sur des rats préentrainés à l'autoadministration de cocaïne, on teste l'autoadministration de différents antihistaminiques. Tous les singes testés s'autoadministrent la tripélennamine et la chlorphéniramine. Aucun ne s'administre la phényltoloxamine, la cimétidine et l'hydroxyzine. Un seul s'administre la pyrilamine, mais à dose élevée. Ceci illustre les différences entre les antagonistes H1 et leur potentiel d'autoadministration, et suggère que leurs propriétés analogues de stimulants, quand elles existent, peuvent compléter l'effet de renforcement.
ENGLISH :
Rhesus monkeys were trained to lever press for infusions of cocaine during daily, 1h experimental sessions. Following stabilization of the cocaine-maintened baselines, various antihistamines were substituted for cocaine. The results indicated that all monkeys tested self-administered tripelennamine and chlorpheniramine. One monkey of the four self-administered pyrilamine, but only at a single (300micro g./kg)high dose. Phenyltoloxamine, cimetidine and hydroxyzine were not self-administered. These results further illuminate differences amongst H1 antagonists in their potential for self-administration and, suggest that stimulant-like properties may help mediate their reinforcing effects when present. (Extract from author's abstract)
Affiliation :
Dept Pharmacol. Toxicol., Box 613 MCV Station, Richmond VA 23298-0613
Etats-Unis. United States.
Etats-Unis. United States.