Historique
Périodique
Triazolam as a discriminative stimulus in humans
(Le triazolam: effet discriminatoire chez l'homme)
Auteur(s) :
OLIVETO, A. H. ;
BICKEL, W. K. ;
HUGHES, J. R. ;
HIGGINS, S. T. ;
FENWICK J.W.
Année
1992
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
38
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1992, 30, 133-142
Résumé :
FRANÇAIS :
Le processus discriminatoire utilisé pour les modèles animaux a été récemment appliqué chez l'homme. Le triazolam est administré ici à 7 volontaires sains. L'expérience montre que la discrimination triazolam-placebo peut-être acquise et que l'effet de stimulus discriminatoire est lié à la dose.
ENGLISH :
Seven healthy male and female volunteers (19-42 years) were trained to discriminate between the benzodiazepine triazolam (0.32mg/70kg;eg drug A) and placebo (eg. drug B). The discrimination was acquired in all subjects ; triazolam (0.32/70kg) and placebo produced approximately 85-95% correct responding. During the dose-effect curve determination, triazolam produced dose-related increases in triazolam-appropriate responding and self-reported sedation and drug strength. These results indicate that a triazolam-placebo discrimination can be acquired and that the triazolam discriminative stimulus effect is related to dose and to self reported sedation. (Extract from author's abstract)
Le processus discriminatoire utilisé pour les modèles animaux a été récemment appliqué chez l'homme. Le triazolam est administré ici à 7 volontaires sains. L'expérience montre que la discrimination triazolam-placebo peut-être acquise et que l'effet de stimulus discriminatoire est lié à la dose.
ENGLISH :
Seven healthy male and female volunteers (19-42 years) were trained to discriminate between the benzodiazepine triazolam (0.32mg/70kg;eg drug A) and placebo (eg. drug B). The discrimination was acquired in all subjects ; triazolam (0.32/70kg) and placebo produced approximately 85-95% correct responding. During the dose-effect curve determination, triazolam produced dose-related increases in triazolam-appropriate responding and self-reported sedation and drug strength. These results indicate that a triazolam-placebo discrimination can be acquired and that the triazolam discriminative stimulus effect is related to dose and to self reported sedation. (Extract from author's abstract)
Affiliation :
Dept Psychiatr., Yale Univ. Sch. Med., 27 Sylvan Ave, New Haven CT 06519
Etats-Unis. United States.
Etats-Unis. United States.