Historique
Périodique
Biotransformation of 1-méthyl-4-phényl-4-propionoxypiperidine (MPPP) to a neurotoxin (MPP+) using GLC-Mass spectrometry
(Etude de la biotransformation du 1-méthyl-4-phényl-4-propionoxypipéridine (MPPP) en neurotoxine (MPP+) par spectrométrie de masse)
Auteur(s) :
JINDAL S.P. ;
LUTZ, T.
Année
1992
Langue(s) :
Anglais
ISBN :
0193-0818
Refs biblio. :
10
Domaine :
Drogues illicites
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Research Communications in Substances of Abuse, 1992, 13, (2), 137-145
Résumé :
FRANÇAIS :
Par la chromatographie gazeuse et spectrométrie de masse, on identifie les métabolites biologiques du MPPP ("Designer-drug"), et plus particulièrement le MPP+ neurotoxique puissant.
ENGLISH :
Gas chromotographic and gas chromotographic-mass spectrometric techniques were used to identify metabolites of MPPP a designer heroin, in rat urine. MPTP and MPP+ were identified as the major metabolites. MPPP, the native drug and the major metabolite MPTP and MPP+ were quantitated in he biofluid using stable isotope labeled analogs as internal standards in a selected ion monitoring assay. (Author's abstract)
Par la chromatographie gazeuse et spectrométrie de masse, on identifie les métabolites biologiques du MPPP ("Designer-drug"), et plus particulièrement le MPP+ neurotoxique puissant.
ENGLISH :
Gas chromotographic and gas chromotographic-mass spectrometric techniques were used to identify metabolites of MPPP a designer heroin, in rat urine. MPTP and MPP+ were identified as the major metabolites. MPPP, the native drug and the major metabolite MPTP and MPP+ were quantitated in he biofluid using stable isotope labeled analogs as internal standards in a selected ion monitoring assay. (Author's abstract)
Affiliation :
Nathan S. Kline Inst. Psychiatr. Res., Orangeburg, New-York 10962
Etats-Unis. United States.
Etats-Unis. United States.