Historique
Périodique
Cocaine use and withdrawal : the effect on sleep and mood
(L'usage de la cocaïne et le sevrage : l'effet sur le sommeil et sur l'humeur)
Auteur(s) :
WATSON, R. ;
BAKOS, L. ;
COMPTON, P. ;
GAWIN F.
Année
1992
Langue(s) :
Anglais
ISBN :
0095-2990
Refs biblio. :
8
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
American Journal of Drug and Alcohol Abuse, 1992, 18, 21-28
Résumé :
FRANÇAIS :
Etude expérimentale sur 3 usagers récréationnels de cocaïne ; privés de cocaïne pendant 48 heures, ayant par la suite sniffé 1 à 2 g de cocaïne, les patients ont régulièrement fait des compte-rendus de leur humeur, ont subi des prises de sang et des mesures physiologiques (EEG, EOG, EMG), y compris pendant leur sommeil. Analyse des résultats.
ENGLISH :
Three recreational cocaine users (age, 26.7 years), after one adaptation night, spent 5 days and nights in the laboratory where their EEG, EOG, and submental EMG were recorded during all of their sleep. On the second afternoon and evening of the study, subjects used an estimated 1 to 2 g cocaine intranasally. They all slept between 2:00 A.M. and 9.00 A.M. that night. Blood samples were drawn each evening and morning. Absolute plasma cocaine levels and patterns of elimination were consistent with subjects report of dose and time of administration. Mood ratings were made repeatedly throughout the study. There was suppression of REM sleep during the use of cocaine followed by a rebound which is specific to REM sleep and is not seen in other stages of sleep. REM variables subsided to normal levels on the third recovery night following cocaine use. Author's abstract)
Etude expérimentale sur 3 usagers récréationnels de cocaïne ; privés de cocaïne pendant 48 heures, ayant par la suite sniffé 1 à 2 g de cocaïne, les patients ont régulièrement fait des compte-rendus de leur humeur, ont subi des prises de sang et des mesures physiologiques (EEG, EOG, EMG), y compris pendant leur sommeil. Analyse des résultats.
ENGLISH :
Three recreational cocaine users (age, 26.7 years), after one adaptation night, spent 5 days and nights in the laboratory where their EEG, EOG, and submental EMG were recorded during all of their sleep. On the second afternoon and evening of the study, subjects used an estimated 1 to 2 g cocaine intranasally. They all slept between 2:00 A.M. and 9.00 A.M. that night. Blood samples were drawn each evening and morning. Absolute plasma cocaine levels and patterns of elimination were consistent with subjects report of dose and time of administration. Mood ratings were made repeatedly throughout the study. There was suppression of REM sleep during the use of cocaine followed by a rebound which is specific to REM sleep and is not seen in other stages of sleep. REM variables subsided to normal levels on the third recovery night following cocaine use. Author's abstract)
Affiliation :
New Haven Sleep Disorders Ctr, 100 York St., New Haven, CT 06511
Etats-Unis. United States.
Etats-Unis. United States.