Historique
Chapitre
Preclinical assessment of cocaine toxicity: mechanisms and pharmacology)
(Evaluation préclinique de la toxicité de la cocaïne)
Auteur(s) :
WITKIN, J. M. ;
KATZ, J. L.
Année
1992
Langue(s) :
Anglais
ISBN :
1046-9516
Refs biblio. :
55
Domaine :
Drogues illicites / Illicit drugs
Note générale :
NIDA Res. Monogr., 1992, 123, 44-69
Résumé :
FRANÇAIS :
La toxicité de la cocaïne est mal connue et les stratégies de traitement restent imparfaites. Les recherches précliniques apportent une compréhension des mécanismes d'action de la cocaïne et permettent l'élaboration de nouveaux protocoles thérapeutiques.
ENGLISH :
The acute and chronic toxicity of cocaine is not fully understood. Treatment strategies, although generally effective, remain imperfect. There are several areas in which improved medications could be clinically useful. Preclinical drug development efforts can increase understanding of the mechanisms underlying cocaine toxicity, develop functional and predictive models, establish safety of cocaine abuse treatments, and provide new leads in the development of more effective medications to be used in the treatment of drug overdose toxicity and drug abuse.
La toxicité de la cocaïne est mal connue et les stratégies de traitement restent imparfaites. Les recherches précliniques apportent une compréhension des mécanismes d'action de la cocaïne et permettent l'élaboration de nouveaux protocoles thérapeutiques.
ENGLISH :
The acute and chronic toxicity of cocaine is not fully understood. Treatment strategies, although generally effective, remain imperfect. There are several areas in which improved medications could be clinically useful. Preclinical drug development efforts can increase understanding of the mechanisms underlying cocaine toxicity, develop functional and predictive models, establish safety of cocaine abuse treatments, and provide new leads in the development of more effective medications to be used in the treatment of drug overdose toxicity and drug abuse.
Affiliation :
Addict. Res. Ctre, NIDA, POB 5180 Baltimore, MD 21224
Etats-Unis. United States.
Etats-Unis. United States.