Historique
Périodique
Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects
(Etude comparative des effets et du potentiel addictif du lorazépam, de la buspirone et du sécobarbital chez des sujets non dépendants)
Auteur(s) :
SELLERS, E. M. ;
SCHNEIDERMAN J.F. ;
ROMACH M.K. ;
KAPLAN, H. L. ;
SOMER G.R.
Année
1992
Langue(s) :
Anglais
ISBN :
0091-2700
Refs biblio. :
41
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of Clinical Pharmacology, 1992, 12, (2), 79-85
Résumé :
FRANÇAIS :
Les effets pharmacologiques des 3 produits sont comparés chez 15 sujets non consommateur ou faible consommateur de dépresseurs du SNC. Les résultats suggèrent que la buspirone présente le potentiel addictif le plus faible, que les effets du lorazépam sur la mémoire et sur les performances motrices sont plus élevés comparativement aux autres produits, et d'une façon générale, que le potentiel addictif des benzodiazépines a été exagéré, en dépit de leurs propriétés de renforcement dans certaines circonstances.
ENGLISH :
The pharmacologic effects of lorazepam (2 mg), buspirone (20 mg, 10 mg), secobarbital (100 mg), and placebo were compared in 15 male, experienced, intermittent nontherapeutic drug users. All drugs produced a "drug effect", however, buspirone 20 mg was significantly less liked than were lorazepam, secobarbital, or buspirone 10 mg (p < .05) but not placebo. Compared with other drugs, lorazepam drug effects were greater and resulted in more prolonged impairment of a motor tracking task, standing steadiness, and memory. Subjects were more likely to identify buspirone as unfamiliar. Because buspirone 20 mg was less liked than were other drugs, dose escalation as part of drug abuse is not likely to occur. Lorazepam also was not particulary liked and was not different from placebo on most subjective abuse-relevant measures.(Extract from author's abstract)
Les effets pharmacologiques des 3 produits sont comparés chez 15 sujets non consommateur ou faible consommateur de dépresseurs du SNC. Les résultats suggèrent que la buspirone présente le potentiel addictif le plus faible, que les effets du lorazépam sur la mémoire et sur les performances motrices sont plus élevés comparativement aux autres produits, et d'une façon générale, que le potentiel addictif des benzodiazépines a été exagéré, en dépit de leurs propriétés de renforcement dans certaines circonstances.
ENGLISH :
The pharmacologic effects of lorazepam (2 mg), buspirone (20 mg, 10 mg), secobarbital (100 mg), and placebo were compared in 15 male, experienced, intermittent nontherapeutic drug users. All drugs produced a "drug effect", however, buspirone 20 mg was significantly less liked than were lorazepam, secobarbital, or buspirone 10 mg (p < .05) but not placebo. Compared with other drugs, lorazepam drug effects were greater and resulted in more prolonged impairment of a motor tracking task, standing steadiness, and memory. Subjects were more likely to identify buspirone as unfamiliar. Because buspirone 20 mg was less liked than were other drugs, dose escalation as part of drug abuse is not likely to occur. Lorazepam also was not particulary liked and was not different from placebo on most subjective abuse-relevant measures.(Extract from author's abstract)
Affiliation :
Addict. Res. Fdn, 33 Russell st, Toronto, ON
Canada. Canada.
Canada. Canada.