Historique
Périodique
Cardiovascular effects and toxicities of cocaine
(Action cardiovasculaire et toxicité de la cocaïne)
Auteur(s) :
NADEMANEE K.
Année
1992
Langue(s) :
Anglais
ISBN :
1055-0887
Refs biblio. :
28
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
COCAINE
;
TOXICITE
;
EFFET SECONDAIRE
;
APPAREIL CARDIOVASCULAIRE
;
SYSTEME NERVEUX CENTRAL
;
PATHOLOGIE
Note générale :
Journal of Addictive Diseases, 1992, 11, (4), 71-82
Résumé :
FRANÇAIS :
Article de synthèse traitant des effets pharmacologiques de la cocaïne, et des conséquences de son usage sur le système cardiovasculaire.
ENGLISH :
Cocaine exerts a myriad of adverse cardiovascular effects which are dependent on the dose, rate of administration, and duration of use. The drug has two primary pharmacologic actions: it is a powerful sympathomimetic agent and a local anesthetic. The drug blocks the presynaptic reuptake of catecholamines resulting in the marked hormonal increase at the postsynaptic receptor sites. These effects, in turn, lower the threshold for coronary vasoconstriction and vasospasm, myocardial ischemia and infarction. In addition, the drug's multiple pharmacologic and electrophysiologic cardiovascular actions can promote arrhythmias, myocarditis, cardiomyopathy, as well as unmasking subclinical diseases. (Extract from author's abstract)
Article de synthèse traitant des effets pharmacologiques de la cocaïne, et des conséquences de son usage sur le système cardiovasculaire.
ENGLISH :
Cocaine exerts a myriad of adverse cardiovascular effects which are dependent on the dose, rate of administration, and duration of use. The drug has two primary pharmacologic actions: it is a powerful sympathomimetic agent and a local anesthetic. The drug blocks the presynaptic reuptake of catecholamines resulting in the marked hormonal increase at the postsynaptic receptor sites. These effects, in turn, lower the threshold for coronary vasoconstriction and vasospasm, myocardial ischemia and infarction. In addition, the drug's multiple pharmacologic and electrophysiologic cardiovascular actions can promote arrhythmias, myocarditis, cardiomyopathy, as well as unmasking subclinical diseases. (Extract from author's abstract)
Affiliation :
Denver Gen. Hosp., 660 Bannock St, Denver, CO 80204
Etats-Unis. United States.
Etats-Unis. United States.