Historique
Périodique
Effects of cocaine self-administration on ethanol, food and water intake in the rat
(Effets de la cocaïne sur l'autoadministration d'alcool, de nourriture et d'eau chez le rat)
Auteur(s) :
HUDZIK T. J. ;
WESSINGER W. D. ;
McMILLAN, D. E.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
23
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence , 1993, 33, 225-234
Résumé :
FRANÇAIS :
Alcool et cocaïne sont souvent utilisées en association par les toxicomanes. Chez le rat, l'autoadministration concurrente de cocaïne et d'alcool peut résulter en une augmentation fonctionnelle des doses de cocaïne.
ENGLISH :
Because cocaine and ethanol are frequently abused in combination, the present study was performed to assess the behavioral consequences of concurrent access to both of these drugs. Self-administration of cocaine resulted in small decreases in ethanol and food intake, as well as some changes in the pattern of ethanol intake. However, removing the ethanol from the chambers had no effect upon food and cocaine intake. Substitution of saline for the cocaine altered the pattern, but not the amount of ethanol intake. There was a trend toward increased ethanol intake during the study, which may have been related to repeated cycles of cocaine availability.
Alcool et cocaïne sont souvent utilisées en association par les toxicomanes. Chez le rat, l'autoadministration concurrente de cocaïne et d'alcool peut résulter en une augmentation fonctionnelle des doses de cocaïne.
ENGLISH :
Because cocaine and ethanol are frequently abused in combination, the present study was performed to assess the behavioral consequences of concurrent access to both of these drugs. Self-administration of cocaine resulted in small decreases in ethanol and food intake, as well as some changes in the pattern of ethanol intake. However, removing the ethanol from the chambers had no effect upon food and cocaine intake. Substitution of saline for the cocaine altered the pattern, but not the amount of ethanol intake. There was a trend toward increased ethanol intake during the study, which may have been related to repeated cycles of cocaine availability.
Affiliation :
Div. Biol. , Fisous Pharmac. , POB , 1710, Rochester, NY 14603
Etats-Unis. United States.
Etats-Unis. United States.