Historique
Périodique
Orally self-administered cocaine in rhesus monkeys : transition from negative or neutral behavioral effects to positive reinforcing effects
(Administration orale de cocaïne chez les singes rhésus : transition entre les effets comportementaux neutres ou négatifs et les effets de renforcement positif.)
Auteur(s) :
MEISCH, R. A. ;
BELL, S. M. ;
LEMAIRE, G. A.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
19
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
INTERACTION CHIMIQUE
;
ALCOOL
;
AUTOADMINISTRATION
;
COMPORTEMENT
;
ANIMAL
Note générale :
Drug and Alcohol Dependence , 1993, 32, 143-158
Résumé :
FRANÇAIS :
Une solution d'alcool à 2% produit un effet de renforcement chez les singes testés. La substitution de l'alcool par la combinaison alcool + cocaïne entraine un taux plus élevé de réponses qu'avec l'alcool seul. La cocaïne a un effet de renforcement observé chez la majorité des singes.
ENGLISH :
The establishment of orally delivered cocaine as a reinforcer was examined with nine rhesus monkeys. Test sessions compared relative rates of responding maintained by two concurrently available drug solutions : a solution containing the combination of ethanol and cocaine used in the prior training block and a solution containing the same concentration of ethanol but with no cocaine. Thus, differences in rates of behavior maintained by the two solutions could be attributed to the presence of cocaine and the existence and degree of any such differences could be monitored at each step in the acquisition procedure. That cocaine had been established as a reinforcer was confirmed by persistent and orderly responding when dose and fixed-ratio size were subsequently varied. (From the author's abstract)
Une solution d'alcool à 2% produit un effet de renforcement chez les singes testés. La substitution de l'alcool par la combinaison alcool + cocaïne entraine un taux plus élevé de réponses qu'avec l'alcool seul. La cocaïne a un effet de renforcement observé chez la majorité des singes.
ENGLISH :
The establishment of orally delivered cocaine as a reinforcer was examined with nine rhesus monkeys. Test sessions compared relative rates of responding maintained by two concurrently available drug solutions : a solution containing the combination of ethanol and cocaine used in the prior training block and a solution containing the same concentration of ethanol but with no cocaine. Thus, differences in rates of behavior maintained by the two solutions could be attributed to the presence of cocaine and the existence and degree of any such differences could be monitored at each step in the acquisition procedure. That cocaine had been established as a reinforcer was confirmed by persistent and orderly responding when dose and fixed-ratio size were subsequently varied. (From the author's abstract)
Affiliation :
Dept. Psychiatr. Behav. Sci. , 1300 Moursund St. , Univ. Texas Hlth Sci. Ctr. , Houston TX
Etats-Unis. United States.
Etats-Unis. United States.