Historique
Périodique
Assessing the behavioral effects and abuse potential of propofol bolus injections in healthy volunteers
(Evaluation des effets comportementaux et du potentiel addictif du propofol chez des volontaires sains)
Auteur(s) :
ZACNY, J. P. ;
LICHTOR J.L. ;
ZARAGOZA, J. G. ;
COALSON, D. W. ;
UITVLUGT A.M. ;
FLEMMING D.C. ;
BINSTOCK, W. B. ;
CUTTER T. ;
APFELBAUM, J. L.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
38
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1993, 32, 45-57
Résumé :
FRANÇAIS :
Après injection à 10 volontaires de propofol (agent anesthesiant) à doses sub-anesthésiques, ou de placebo, on étudie les effets subjectifs sur l'humeur, la mémoire et les performances psychomotrices. Il en est déduit que le propofol peut avoir un pouvoir toxicomanogène et qu'il existe un risque de détournement par le personnel médical.
ENGLISH :
Propofol is a recently introduced intravenous anesthetic agent. We examined various effects of this agent at different subanesthetic doses (0.2-0.6 mg/kg) in order to characterize this drug's abuse potential (for recreational use or potential for diversion). Healthy normal volunteers (N = 10) were injected intravenously with the drug or with placebo. Before the injection and for up to 1 h afterwards, mood (including drug liking), memory and psychomotor performance were assessed. Propofol impaired memory and psychomotor performance and produced changes in 10 of 20 VAS mood ratings. Although there was variability in self-reported drug liking, some subjects clearly liked the effects of propofol, especially at the two higher doses. These preliminary results suggest that this agent may have some potential for abuse/diversion and perhaps stricter accountability procedures should be established for this drug in settings where general anesthesia or conscious sedation procedures are done. (Extract from authors'abstract)
Après injection à 10 volontaires de propofol (agent anesthesiant) à doses sub-anesthésiques, ou de placebo, on étudie les effets subjectifs sur l'humeur, la mémoire et les performances psychomotrices. Il en est déduit que le propofol peut avoir un pouvoir toxicomanogène et qu'il existe un risque de détournement par le personnel médical.
ENGLISH :
Propofol is a recently introduced intravenous anesthetic agent. We examined various effects of this agent at different subanesthetic doses (0.2-0.6 mg/kg) in order to characterize this drug's abuse potential (for recreational use or potential for diversion). Healthy normal volunteers (N = 10) were injected intravenously with the drug or with placebo. Before the injection and for up to 1 h afterwards, mood (including drug liking), memory and psychomotor performance were assessed. Propofol impaired memory and psychomotor performance and produced changes in 10 of 20 VAS mood ratings. Although there was variability in self-reported drug liking, some subjects clearly liked the effects of propofol, especially at the two higher doses. These preliminary results suggest that this agent may have some potential for abuse/diversion and perhaps stricter accountability procedures should be established for this drug in settings where general anesthesia or conscious sedation procedures are done. (Extract from authors'abstract)
Affiliation :
Dept Anesth., MC 4028, 5841 S Maryland Ave, Chicago, IL 60637
Etats-Unis. United States.
Etats-Unis. United States.