Historique
Périodique
Pharmacological options for management of opioid dependence
(Choix pharmacologiques pour le traitement de la dépendance aux opiacés)
Auteur(s) :
CHRISTIE, M. J. ;
HARVEY A.I.
Année
1993
Langue(s) :
Anglais
ISBN :
0959-5236
Refs biblio. :
67
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
BUPRENORPHINE
;
METHADONE
;
HEROINE
;
NALTREXONE
;
SEVRAGE
;
TRAITEMENT
;
ACCOUTUMANCE
;
TRAITEMENT DE MAINTENANCE
;
ADAPTATION
Note générale :
Drug and Alcohol Review, 1993, 12, 71-80
Résumé :
FRANÇAIS :
La méthadone est présentée comme l'opiacé de choix pour le traitement de la dépendance aux opiacés. Elle a toutefois ses limites d'utilisation. La buprénorphine et la naltrexone sont utilisables. Les indications et les propriétés pharmacologiques de ces produits sont discutées.
ENGLISH :
Methadone is currently the only opiod available for the pharmacotherapy of opiod dependence. Cross-tolerance between methadone and other opioids constitutes the pharmacological basis for substitution and attenuating the effects of illicit opioid use. However, these principles limit the utility of methadone. Bruprenorphine is an alternative to methadone. It has a large margin of safety, yet displays some agonist actions similar to methadone. It has greater potential than methadone to safely and effectively block the actions of illicit opioids. Naltrexone is a safe, convenient opioid-antagonist for use following detoxification from opioid agonists. It main use is to block the actions of other opioids, thereby attenuating or eliminating illicit use during treatment. However, it is poorly accepted by many clients. The distinct pharmacological properties of these opioids can overcome some of the drawbacks of methadone, but other limitations may emerge.(Extract from the author's abstract)
La méthadone est présentée comme l'opiacé de choix pour le traitement de la dépendance aux opiacés. Elle a toutefois ses limites d'utilisation. La buprénorphine et la naltrexone sont utilisables. Les indications et les propriétés pharmacologiques de ces produits sont discutées.
ENGLISH :
Methadone is currently the only opiod available for the pharmacotherapy of opiod dependence. Cross-tolerance between methadone and other opioids constitutes the pharmacological basis for substitution and attenuating the effects of illicit opioid use. However, these principles limit the utility of methadone. Bruprenorphine is an alternative to methadone. It has a large margin of safety, yet displays some agonist actions similar to methadone. It has greater potential than methadone to safely and effectively block the actions of illicit opioids. Naltrexone is a safe, convenient opioid-antagonist for use following detoxification from opioid agonists. It main use is to block the actions of other opioids, thereby attenuating or eliminating illicit use during treatment. However, it is poorly accepted by many clients. The distinct pharmacological properties of these opioids can overcome some of the drawbacks of methadone, but other limitations may emerge.(Extract from the author's abstract)
Affiliation :
Dept Pharmacol., Univ. Sydney, NSW 2006
Australie. Australia.
Australie. Australia.