Historique
Périodique
Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant : relevance for alcoholism and drug abuse
(Carte génétique du locus du gène Taq I "A", du récepteur de la Dopamine D2, incluant le variant A4: rapport avec l'alcoolisme et la toxicomanie)
Auteur(s) :
PERSICO, A. M. ;
O'HARA B.F. ;
FARMER, S. ;
GYSIN R. ;
FLANAGAN S.D. ;
UHL, G. R.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
25
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1993, 31, 229-234
Résumé :
FRANÇAIS :
Des recombinaisons génétiques réalisées à partir de différents allèles du gène du récepteur de la Dopamine D2, permettent de relier l'absence de certains sites (dans les allèles A1, A4) à une prédisposition à la toxicomanie.
ENGLISH :
The D2 dopamine receptor gene (DRD2) displays Taq 1 restriction fragment length polymorphisms (RFLPs) at two different loci, termed A and B. One of the three different Taq 1 A 'alleles' described at this site, the A1 allele (size = 6,6 kb), has been found to be associated with alcoholism and with drug abuse in the majority of studies reported to date. A complete map of the Taq 1 A RFLP site has been constructed. The A4, but not the A3 'allele', displays substantial overlap with the A1. In particular, A2 and A3 share the presence of a Taq 1 restriction site, whose absence in A1 and A4 is apparently associated with substance abuse vulnerability. Therefore, in association studies it is proper to contrast individuals displaying A1 and A4 RFLP patterns, with individuals displaying A2 and A3 RFLPs. (Extract from author's abstract)
Des recombinaisons génétiques réalisées à partir de différents allèles du gène du récepteur de la Dopamine D2, permettent de relier l'absence de certains sites (dans les allèles A1, A4) à une prédisposition à la toxicomanie.
ENGLISH :
The D2 dopamine receptor gene (DRD2) displays Taq 1 restriction fragment length polymorphisms (RFLPs) at two different loci, termed A and B. One of the three different Taq 1 A 'alleles' described at this site, the A1 allele (size = 6,6 kb), has been found to be associated with alcoholism and with drug abuse in the majority of studies reported to date. A complete map of the Taq 1 A RFLP site has been constructed. The A4, but not the A3 'allele', displays substantial overlap with the A1. In particular, A2 and A3 share the presence of a Taq 1 restriction site, whose absence in A1 and A4 is apparently associated with substance abuse vulnerability. Therefore, in association studies it is proper to contrast individuals displaying A1 and A4 RFLP patterns, with individuals displaying A2 and A3 RFLPs. (Extract from author's abstract)
Affiliation :
NIDA Addict. Res. Ctr, POB 5180 Baltimore MD 21224
Etats-Unis. United States.
Etats-Unis. United States.