Historique
Périodique
Reinforcing effects of extended inhalation of nitrous oxide in humans
(Effets de renforcement suite à une inhalation prolongée de protoxyde d'azote chez l'homme)
Auteur(s) :
DOHRN C.S. ;
LICHTOR J.L. ;
COALSON, D. W. ;
UITVLUGT A. ;
DE WIT, H. ;
ZACNY, J. P.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1993, 31, 265-280
Résumé :
FRANÇAIS :
L'expérience d'inhalation de différentes concentrations de protoxyde d'azote, menée ici sur des volontaires sains, montre peu d'effets de renforcement, contrairement à d'autres études préalables.
ENGLISH :
The subjective, psychomotor and reinforcing effects of nitrous oxide at subanesthetic doses (30% and 40% in oxygen) were determined in normal healthy volunteers using a choice paradigm. Thirty percent nitrous oxide was chosen no more often than oxygen (41,6% choice rate), indicating that, for most of the subjects tested, extended inhalation of this nitrous oxide concentration was no more reinforcing than oxigen inhalation. Forty percent nitrous oxide was chosen significantly less often than oxygen (22% choice rate), indicating that, for most of the subjects tested, extended inhalation of this nitrous oxide concentration was less reinforcing than oxygen. Nitrous oxide produced robust subjective effects (e.g., increased ratings of 'high', 'tingling'). The lack of reinforcing effects noted in the present study, given nitrous oxide's known abuse potential is discussed. (Extract from author's abstract)
L'expérience d'inhalation de différentes concentrations de protoxyde d'azote, menée ici sur des volontaires sains, montre peu d'effets de renforcement, contrairement à d'autres études préalables.
ENGLISH :
The subjective, psychomotor and reinforcing effects of nitrous oxide at subanesthetic doses (30% and 40% in oxygen) were determined in normal healthy volunteers using a choice paradigm. Thirty percent nitrous oxide was chosen no more often than oxygen (41,6% choice rate), indicating that, for most of the subjects tested, extended inhalation of this nitrous oxide concentration was no more reinforcing than oxigen inhalation. Forty percent nitrous oxide was chosen significantly less often than oxygen (22% choice rate), indicating that, for most of the subjects tested, extended inhalation of this nitrous oxide concentration was less reinforcing than oxygen. Nitrous oxide produced robust subjective effects (e.g., increased ratings of 'high', 'tingling'). The lack of reinforcing effects noted in the present study, given nitrous oxide's known abuse potential is discussed. (Extract from author's abstract)
Affiliation :
Dept Anesth. Crit. Care, Box MC 4028, Univ. Chicago, 5841 S. Maryland Ave, Chicago, IL 60637
Etats-Unis. United States.
Etats-Unis. United States.