Historique
Périodique
Effects of mazindol on behavior maintained or occasioned by cocaine
(Effets du mazindol sur le comportement maintenu ou provoqué par la cocaïne)
Auteur(s) :
MANSBACH R.S. ;
BALSTER, R. L.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
20
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1993, 31, 183-191
Résumé :
FRANÇAIS :
Le mazindol, malgré son manque de sélectivité, se présente comme un inhibiteur susceptible d'être utilisé dans la pharmacothérapie de l'abus de stimulants.
ENGLISH :
the effects of mazindol, cocaine and D-amphetamine were studied in rhesus monkeys trained to self-administer cocaine, and in rats and squirrel monkeys trained to discriminate cocaine from saline. Despite a lack of selectivity to decrease cocaine self-administration as compared to behavior maintained by food, the present data provide some rationale for further consideration of mazindol as a potential pharmacotherapy for stimulant abuse, due to its relatively low abuse liability and cocaine-like discriminative stimulus effects.
Le mazindol, malgré son manque de sélectivité, se présente comme un inhibiteur susceptible d'être utilisé dans la pharmacothérapie de l'abus de stimulants.
ENGLISH :
the effects of mazindol, cocaine and D-amphetamine were studied in rhesus monkeys trained to self-administer cocaine, and in rats and squirrel monkeys trained to discriminate cocaine from saline. Despite a lack of selectivity to decrease cocaine self-administration as compared to behavior maintained by food, the present data provide some rationale for further consideration of mazindol as a potential pharmacotherapy for stimulant abuse, due to its relatively low abuse liability and cocaine-like discriminative stimulus effects.
Affiliation :
Dept Pharmacol. Toxicol., Med. Coll. Virginia, Richmond VA 23298-0613
Etats-Unis. United States.
Etats-Unis. United States.