Historique
Article de Périodique
Sensitivity to subjective effects of cocaine in drug abusers : relationship to cerebral ventricle size (1993)
(Sensibilité aux effets subjectifs de la cocaïne chez les usagers de drogue : relation avec la taille du ventricule cérébral)
Auteur(s) :
MORGAN, M. J. ;
CASCELLA, N. G. ;
STAPLETON J.M. ;
PHILLIPS, R. L. ;
YUNG B.C.K. ;
WONG, D. F. ;
SHAYA E.K. ;
LONDON E.D.
Année
1993
Page(s) :
1712-1717
Langue(s) :
Anglais
Refs biblio. :
47
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Résumé :
FRANÇAIS :
Les relations entre le VBR (Ventricle Brain Ratio = rapport ventricule cerveau) et des réponses subjectives à l'injection de l'hydrochloride de cocaïne sont examinées chez 20 polytoxicomanes hommes. Des tests de mesure du métabolisme du glucose cérébral sont faits. Les résultats sont corrélés avec les scores obtenus sur des échelles de dépendance.
ENGLISH :
Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism. Subjective measures of effects of cocaine, including self-report ratings of intensity of the drug effect, scores on the morphine-benzedrine scale of the Addiction Research Center. Inventory, and several items on visual analogue scales, correlated negatively with VBR. VBR also differed significantly among subjects who were grouped according to scores on items ("rush" and "crash") of the Cocaine-Sensitive Scale (larger VBR in subjects with weaker responses). VBR was not correlated with cocaine-included changes in cerebral metabolic rates for glucose. Conclusions : Relative insensitivity to the subjective effects of cocaine in polydrug abusers with ventricle enlargement suggests that ventriculomegaly may reflect changes in periventricular brain regions that mediate these effects of cocaine. (Extract from authors'abstract)
Les relations entre le VBR (Ventricle Brain Ratio = rapport ventricule cerveau) et des réponses subjectives à l'injection de l'hydrochloride de cocaïne sont examinées chez 20 polytoxicomanes hommes. Des tests de mesure du métabolisme du glucose cérébral sont faits. Les résultats sont corrélés avec les scores obtenus sur des échelles de dépendance.
ENGLISH :
Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism. Subjective measures of effects of cocaine, including self-report ratings of intensity of the drug effect, scores on the morphine-benzedrine scale of the Addiction Research Center. Inventory, and several items on visual analogue scales, correlated negatively with VBR. VBR also differed significantly among subjects who were grouped according to scores on items ("rush" and "crash") of the Cocaine-Sensitive Scale (larger VBR in subjects with weaker responses). VBR was not correlated with cocaine-included changes in cerebral metabolic rates for glucose. Conclusions : Relative insensitivity to the subjective effects of cocaine in polydrug abusers with ventricle enlargement suggests that ventriculomegaly may reflect changes in periventricular brain regions that mediate these effects of cocaine. (Extract from authors'abstract)
Affiliation :
NIDA Addict. Res. Ctr, POB 5180 Baltimore, MD 21224
Etats-Unis. United States.
Etats-Unis. United States.