Historique
Périodique
Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus
(Facteurs de diminution du taux de lymphocytes CD4+ parmi les toxicomanes intraveineux contaminés par le VIH)
Auteur(s) :
ALCABES, P. ;
SCHOENBAUM, E. E. ;
KLEIN, R. S.
Année
1993
Langue(s) :
Anglais
ISBN :
0002-9262E
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
VOIE INTRAVEINEUSE
;
SEROPOSITIVITE
;
SIDA
;
BACTERIE
;
INFECTION
;
EPIDEMIOLOGIE
Note générale :
American Journal of Epidemiology, 1993, 137, (9), 989-1000
Résumé :
FRANÇAIS :
De 1985 à 1990, à New York, on a mesuré la perte des lymphocytes CD4 chez 318 toxicomanes intraveineux séropositifs. Dans cette population, le taux de perte moyen des CD4 est de 1,33% sur 6 mois. Les facteurs cliniques prédictifs d'une évolution rapide vers le SIDA sont liés notamment à la présence d'infections bactériennes.
ENGLISH :
Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989. Follow-up continued through 1990. The percentage of CD4+ T-lymphocytes (CD4%) was used to maximize the stability of measurements. The rate of decline of the CD4% was determined using a random-effects assumption, and predictors of decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost). The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (CI) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% CI 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% CI 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% CI 0.01-0.27). Oral thrush was not related to an accelerated rate of CD4% decline. (Author's abstract)
De 1985 à 1990, à New York, on a mesuré la perte des lymphocytes CD4 chez 318 toxicomanes intraveineux séropositifs. Dans cette population, le taux de perte moyen des CD4 est de 1,33% sur 6 mois. Les facteurs cliniques prédictifs d'une évolution rapide vers le SIDA sont liés notamment à la présence d'infections bactériennes.
ENGLISH :
Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989. Follow-up continued through 1990. The percentage of CD4+ T-lymphocytes (CD4%) was used to maximize the stability of measurements. The rate of decline of the CD4% was determined using a random-effects assumption, and predictors of decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost). The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (CI) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% CI 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% CI 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% CI 0.01-0.27). Oral thrush was not related to an accelerated rate of CD4% decline. (Author's abstract)
Affiliation :
Yales Aids Prog., 495 Congress ave, Welch 2D, New Haven, CT 06519
Etats-Unis. United States.
Etats-Unis. United States.