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The effects of delay of reinforcement and dose on the self-administration of cocaine and procaine in rehsus monkeys
(Etude du renforcement différé et de la dose de cocaïne et de procaïne sur l'autoadministration chez les singes rhésus)
Auteur(s) :
BEARDSLEY, P. M. ;
BALSTER, R. L.
Année
1993
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence , 1993, 34, 37-43
Résumé :
FRANÇAIS :
Dans des expériences où on impose un retard de renforcement, on constate qu'aux doses élevées de procaïne et de cocaïne les singes offrent un plus grande résistance au changement apporté par un retard de renforcement. En extrapolant à l'homme, on suggère que les dépendances basées sur la préparation et la voie d'administration sont les plus difficiles à traiter.
ENGLISH :
The results indicated that during both baseline and delay conditions increases in dose of either drug resulted in increases followed by decreases in the number of influsions obtained. Introducing delays of reinforcement resulted in decreases in the number of infusions obtained at a given dose. Genernally, however, when reinforcement delays were imposed the decreases in infusion number, as a percentage of baseline number, were less at the higher doses of both drugs. The doses of procaine which were maximally effective as reinforcers (i.e. during which infusion number was minimally reduced by delay) were as effective as the maximally effective doses of cocaine. These results suggest that drug preparations and routes of administration which, in fact, maximize unit dose delivery would also maximize the likelihood that drug-maintained behavior will be resistant to therapeutic intervention.
Dans des expériences où on impose un retard de renforcement, on constate qu'aux doses élevées de procaïne et de cocaïne les singes offrent un plus grande résistance au changement apporté par un retard de renforcement. En extrapolant à l'homme, on suggère que les dépendances basées sur la préparation et la voie d'administration sont les plus difficiles à traiter.
ENGLISH :
The results indicated that during both baseline and delay conditions increases in dose of either drug resulted in increases followed by decreases in the number of influsions obtained. Introducing delays of reinforcement resulted in decreases in the number of infusions obtained at a given dose. Genernally, however, when reinforcement delays were imposed the decreases in infusion number, as a percentage of baseline number, were less at the higher doses of both drugs. The doses of procaine which were maximally effective as reinforcers (i.e. during which infusion number was minimally reduced by delay) were as effective as the maximally effective doses of cocaine. These results suggest that drug preparations and routes of administration which, in fact, maximize unit dose delivery would also maximize the likelihood that drug-maintained behavior will be resistant to therapeutic intervention.
Affiliation :
Dept Pharmacol. , Med. Coll. Virginia, Virginia Commonwealth Univ. , Box 613 Mcv Station, Richmond VA 23298-0613
Etats-Unis. United States.
Etats-Unis. United States.